2. Others Metabolic Enzyme/Protease
  3. Environmental Pollutants Herbicide
  4. 3,5,6-Trichloro-2-pyridinol

3,5,6-Trichloro-2-pyridinol  (Synonyms: 3,5,6-トリクロロピリジン-2-オール)

製品番号: HY-W018171 純度: 99.85%
COA 取扱説明書 Technical Support

3,5,6-Trichloro-2-pyridinol (TCPy) is a chloride of 2-pyridone with oral activity. 3,5,6-Trichloro-2-pyridinol is the main degradation product of the herbicide Triclopyr and the insecticides Chlorpyrifos and chlorpyrifos-methyl. 3,5,6-Trichloro-2-pyridinol is associated with attention deficit hyperactivity disorder (ADHD) and decreased testosterone levels. 3,5,6-Trichloro-2-pyridinol causes hearing loss, hepatotoxicity and nephrotoxicity in mice .

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3,5,6-Trichloro-2-pyridinol

3,5,6-Trichloro-2-pyridinol 構造式

CAS 番号 : 6515-38-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Solid
500 mg $30 在庫あり
1 g $45 在庫あり
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Other Forms of 3,5,6-Trichloro-2-pyridinol:

3,5,6-Trichloro-2-pyridinol 関連抗体

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製品説明

3,5,6-Trichloro-2-pyridinol (TCPy) is a chloride of 2-pyridone with oral activity. 3,5,6-Trichloro-2-pyridinol is the main degradation product of the herbicide Triclopyr and the insecticides Chlorpyrifos and chlorpyrifos-methyl. 3,5,6-Trichloro-2-pyridinol is associated with attention deficit hyperactivity disorder (ADHD) and decreased testosterone levels. 3,5,6-Trichloro-2-pyridinol causes hearing loss, hepatotoxicity and nephrotoxicity in mice [1][2][3][4][5].

体内実験

3,5,6-Trichloro-2-pyridinol (50-150 mg/kg, 21 days) can cause oxidative stress, inflammation, and imbalance of cochlear potential in the cochlea, induce cochlear DNA damage and apoptosis, and cause cochlear morphological changes, eventually leading to impaired hearing function[4].
3,5,6-Trichloro-2-pyridinol (5-150 mg/kg, daily for 28 days) induces hepatotoxicity and nephrotoxicity, as well as metabolic disturbances[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male mice[5]
Dosage: 5, 50, 150 mg/kg
Administration: Oral gavage (p.o.), daily for 28 days
Result: The final body weights of treated groups were significantly lower than control, and the relative organ weights of the liver and kidney were significantly higher than that of control.
A total of 39 serum metabolites were significantly changed in the treated groups, and these metabolites are related to hepatotoxicity and nephrotoxicity.
Metabolic disturbances were also observed.
Animal Model: adult male C57BL/6 mice[4]
Dosage: 50, 150 mg/kg
Administration: 21 days
Result: Showed a dose-dependent elevation of hearing threshold.
Outer hair cells and spiral neuron cells were lost in a dose-dependent manner.
Type I and V of spiral ligament were severely shrunk and stria vascularis were thinned.
ROS levels in the cochlea were significantly increased whereas the activities of anti-oxidation enzymes were decreased.
The expression level of Na+/K+ ATPase was decreased, resulting in cochlear potential disruption.
Levels of inflammatory factors (TNF-α and IL-1β), γ-H2AX, and pro-apoptotic-related factors (Bax and cleaved-Caspase 3) were elevated, respectively.
分子量

198.43

分子式

C5H2Cl3NO
CAS 番号
Appearance

Solid

Color

Off-white to gray

SMILES

O=C1C(Cl)=CC(Cl)=C(Cl)N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 32.5 mg/mL (163.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0396 mL 25.1978 mL 50.3956 mL
5 mM 1.0079 mL 5.0396 mL 10.0791 mL
10 mM 0.5040 mL 2.5198 mL 5.0396 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

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体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 3.25 mg/mL (16.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 3.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 3.25 mg/mL (16.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 3.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.85%

COA (252 KB) HNMR (239 KB) LCMS (86 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.0396 mL 25.1978 mL 50.3956 mL 125.9890 mL
5 mM 1.0079 mL 5.0396 mL 10.0791 mL 25.1978 mL
10 mM 0.5040 mL 2.5198 mL 5.0396 mL 12.5989 mL
15 mM 0.3360 mL 1.6799 mL 3.3597 mL 8.3993 mL
20 mM 0.2520 mL 1.2599 mL 2.5198 mL 6.2995 mL
25 mM 0.2016 mL 1.0079 mL 2.0158 mL 5.0396 mL
30 mM 0.1680 mL 0.8399 mL 1.6799 mL 4.1996 mL
40 mM 0.1260 mL 0.6299 mL 1.2599 mL 3.1497 mL
50 mM 0.1008 mL 0.5040 mL 1.0079 mL 2.5198 mL
60 mM 0.0840 mL 0.4200 mL 0.8399 mL 2.0998 mL
80 mM 0.0630 mL 0.3150 mL 0.6299 mL 1.5749 mL
100 mM 0.0504 mL 0.2520 mL 0.5040 mL 1.2599 mL
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3,5,6-Trichloro-2-pyridinol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,5,6-Trichloro-2-pyridinol6515-38-4TCPyEnvironmental PollutantsHerbicideEnvironmental ContaminantsInhibitorinhibitorinhibit

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製品名:
3,5,6-Trichloro-2-pyridinol
製品番号:
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