6515-38-4
Chemical Structure
3,5,6-Trichloro-2-pyridinol
Synonym(s): TCPy
- CAS No.: 6515-38-4
- Formula:C5H2Cl3NO
- Molecular Weight:198.43
IUPAC Name: 3,5,6-trichloropyridin-2(1H)-one
InChIKey: WCYYAQFQZQEUEN-UHFFFAOYSA-N
SMILES: O=C1C(Cl)=CC(Cl)=C(Cl)N1
Biological Activity: 3,5,6-Trichloro-2-pyridinol (TCPy) is a chloride of 2-pyridone with oral activity. 3,5,6-Trichloro-2-pyridinol is the main degradation product of the herbicide Triclopyr and the insecticides Chlorpyrifos and chlorpyrifos-methyl. 3,5,6-Trichloro-2-pyridinol is associated with attention deficit hyperactivity disorder (ADHD) and decreased testosterone levels. 3,5,6-Trichloro-2-pyridinol causes hearing loss, hepatotoxicity and nephrotoxicity in mice [1][2][3][4][5].
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3,5,6-Trichloro-2-pyridinol | 99.85% | 3,5,6-Trichloro-2-pyridinol (TCPy) is a chloride of 2-pyridone with oral activity. 3,5,6-Trichloro-2-pyridinol is the main degradation product of the herbicide Triclopyr and the insecticides Chlorpyrifos and chlorpyrifos-methyl. 3,5,6-Trichloro-2-pyridinol is associated with attention deficit hyperactivity disorder (ADHD) and decreased testosterone levels. 3,5,6-Trichloro-2-pyridinol causes hearing loss, hepatotoxicity and nephrotoxicity in mice . | ||||||||||||||||||||
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3,5,6-Trichloro-2-pyridinol (Standard) | ≥98% | 3,5,6-Trichloro-2-pyridinol (Standard) is the analytical standard of 3,5,6-Trichloro-2-pyridinol. This product is intended for research and analytical applications. 3,5,6-Trichloro-2-pyridinol (TCPy) is a chloride of 2-pyridone with oral activity. 3,5,6-Trichloro-2-pyridinol is the main degradation product of the herbicide Triclopyr and the insecticides Chlorpyrifos and chlorpyrifos-methyl. 3,5,6-Trichloro-2-pyridinol is associated with attention deficit hyperactivity disorder (ADHD) and decreased testosterone levels. 3,5,6-Trichloro-2-pyridinol causes hearing loss, hepatotoxicity and nephrotoxicity in mice. | ||||||||||||||||||||
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3,5,6-Trichloro-2-pyridinol-13C3 | 3,5,6-Trichloro-2-pyridinol-13C3 (TCPy-13C3) is the 13C-labeled 3,5,6-Trichloro-2-pyridinol (HY-W018171). 3,5,6-Trichloro-2-pyridinol (TCPy) is the main degradation product of the herbicide Triclopyr and the insecticides Chlorpyrifos and Chlorpyrifos-methyl. | |||||||||||||||||||||
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3,5,6-Trichloro-2-pyridinol-13C5 | 3,5,6-Trichloro-2-pyridinol-13C5 (TCPy-13C5) is 13C labeled 3,5,6-Trichloro-2-pyridinol. | |||||||||||||||||||||
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References
- [1]. Jingquan Li, et al. Novel gene clusters and metabolic pathway involved in 3,5,6-trichloro-2-pyridinol degradation by Ralstonia sp. strain T6. Appl Environ Microbiol. 2013 Dec;79(23):7445-53. [Content Brief]
- [2]. Fortenberry GZ, et al. Urinary 3,5,6-trichloro-2-pyridinol (TCPY) in pregnant women from Mexico City: distribution, temporal variability, and relationship with child attention and hyperactivity. Int J Hyg Environ Health. 2014 Mar;217(2-3):405-12. [Content Brief]
- [3]. Meeker JD, et al. Exposure to nonpersistent insecticides and male reproductive hormones. Epidemiology. 2006 Jan;17(1):61-8. [Content Brief]
- [4]. Huang M, et al. Pesticide metabolite 3, 5, 6-trichloro-2-pyridinol causes massive damage to the cochlea resulting in hearing loss in adult mice. Environ Pollut. 2024 Nov 1;360:124691. [Content Brief]
- [5]. Deng Y, et al. Hepatotoxicity and nephrotoxicity induced by the chlorpyrifos and chlorpyrifos-methyl metabolite, 3,5,6-trichloro-2-pyridinol, in orally exposed mice. Sci Total Environ. 2016 Feb 15;544:507-14. [Content Brief]
