3-Methylthiophene-2-carboxylic acid

Cat. No.: HY-W004782: Data Sheet
COA

SDS
Handling Instructions
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3-Methylthiophene-2-carboxylic acid (compound 3) is a potent Pseudomonas quinolone signal system protein E (PqsE) inhibitor with a K_d of 19.6 µM and an IC₅₀ of 40 µM. 3-Methylthiophene-2-carboxylic acid binds to the active center of PqsE and shows inhibition of the thioesterase activity. Methylthiophene-2-carboxylic acid can permeate into P. aeruginosa and affect 2,4-dihydroxyquinoline (DHQ) levels to a similar extent as deletion of the PqsE gene. 3-Methylthiophene-2-carboxylic acid can be used for cystic fibrosis research.

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3-Methylthiophene-2-carboxylic acid 화학구조

CAS No. : 23806-24-8

사이즈	재고	수량
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	해외재고보유	Estimated Time of Arrival: December 31
25 g	해외재고보유	Estimated Time of Arrival: December 31
50 g	해외재고보유	Estimated Time of Arrival: December 31
100 g	해외재고보유	Estimated Time of Arrival: December 31
> 100 g	견적 받기

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Biological Activity
순도&문서
References
고객리뷰

제품 설명	3-Methylthiophene-2-carboxylic acid (compound 3) is a potent Pseudomonas quinolone signal system protein E (PqsE) inhibitor with a K_d of 19.6 µM and an IC₅₀ of 40 µM. 3-Methylthiophene-2-carboxylic acid binds to the active center of PqsE and shows inhibition of the thioesterase activity. Methylthiophene-2-carboxylic acid can permeate into P. aeruginosa and affect 2,4-dihydroxyquinoline (DHQ) levels to a similar extent as deletion of the PqsE gene. 3-Methylthiophene-2-carboxylic acid can be used for cystic fibrosis research^[1].
분자량	142.18
화학식	C₆H₆O₂S
CAS No.	23806-24-8
Appearance	Solid
SMILES	CC(C=CS1)=C1C(O)=O
선적	Room temperature in continental US; may vary elsewhere.
보관	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
순도&문서	Purity: 99.91% Select Batch: Data Sheet (271 KB) SDS (393 KB) COA (254 KB) Handling Instructions (2659 KB)
References	[1]. Zender M, et al. Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds. ACS Chem Biol. 2016 Jun 17;11(6):1755-63.