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  6. 4-epi-Withaferin A

4-epi-Withaferin A (compound 28) is the analogue of Withaferin A. 4-epi-Withaferin A enhances cytotoxicity and cytoprotective heat-shock-inducing activity (HSA). 4-epi-Withaferin A has the potential for the research of protein aggregation-associated diseases by stimulating cellular defense mechanisms.

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4-epi-Withaferin A

4-epi-Withaferin A Chemische Struktur

CAS. Nr. : 1214886-27-7

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4-epi-Withaferin A Related Antibodies

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Beschreibung

4-epi-Withaferin A (compound 28) is the analogue of Withaferin A. 4-epi-Withaferin A enhances cytotoxicity and cytoprotective heat-shock-inducing activity (HSA). 4-epi-Withaferin A has the potential for the research of protein aggregation-associated diseases by stimulating cellular defense mechanisms[1].

Cellular Effect
Cell Line Type Value Description References
HEK-293T IC50
250 nM
Compound: 15
Cytotoxicity against human 293T cells assessed as reduction in cell viability after 72 hrs by resazurin dye based Alamar blue assay
Cytotoxicity against human 293T cells assessed as reduction in cell viability after 72 hrs by resazurin dye based Alamar blue assay
[PMID: 29537263]
NCI-H929 IC50
0.28 μM
Compound: 28
Cytotoxicity against human NCI-H929 cells after 3 days by Alamar blue assay
Cytotoxicity against human NCI-H929 cells after 3 days by Alamar blue assay
[PMID: 24625088]
Molekulargewicht

470.60

Formel

C28H38O6
CAS. Nr.
SMILES

C[C@]12[C@@]3([C@@H](C=CC2=O)O)[C@](C[C@]4([H])[C@]1([H])CC[C@]5([C@@]4([H])CC[C@]5([H])[C@@H]([C@@]6([H])CC(C)=C(C(O6)=O)CO)C)C)([H])O3
Structure Classification
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

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Reinheit & Dokumentation
Verweise
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4-epi-Withaferin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-epi-Withaferin A1214886-27-7OthersWithaferin AcytotoxicitycytoprotectiveHAScellular defense mechanismInhibitorinhibitorinhibit

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