2. Metabolic Enzyme/Protease
  3. Tryptophan Hydroxylase
  4. p-Ethynylphenylalanine

p-Ethynylphenylalanine  (Synonyms: 4-Ethynyl-L-phenylalanine)

製品番号: HY-23460 純度: 99.93%
COA 取扱説明書 Technical Support

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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p-Ethynylphenylalanine

p-Ethynylphenylalanine 構造式

CAS 番号 : 278605-15-5

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Based on 1 publication(s) in Google Scholar

Other Forms of p-Ethynylphenylalanine:

p-Ethynylphenylalanine 関連抗体

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製品説明

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1]. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

Ki: 32.6 μM (TPH)[1]
体外実験

p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin[1].
p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT1, 5-HT2, 5-HT4, 5-HT5, 5-HT6, and 5-HT7)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

p-Ethynylphenylalanine 関連抗体
体内実験

p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (200 g)[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection
Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain.
分子量

189.21

分子式

C11H11NO2
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

1M NaOH : 240 mg/mL (1268.41 mM; ultrasonic and adjust pH to 11 with NaOH)

1M HCl : 240 mg/mL (1268.41 mM; ultrasonic and adjust pH to 1 with HCl)

DMSO : 2.22 mg/mL (11.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2850 mL 26.4251 mL 52.8502 mL
5 mM 1.0570 mL 5.2850 mL 10.5700 mL
10 mM 0.5285 mL 2.6425 mL 5.2850 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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純度とドキュメンテーション

純度: 99.93%

COA (246 KB) RP-HPLC (243 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 1M NaOH / 1M HCl 1 mM 5.2850 mL 26.4251 mL 52.8502 mL 132.1255 mL
5 mM 1.0570 mL 5.2850 mL 10.5700 mL 26.4251 mL
10 mM 0.5285 mL 2.6425 mL 5.2850 mL 13.2126 mL
1M NaOH / 1M HCl 15 mM 0.3523 mL 1.7617 mL 3.5233 mL 8.8084 mL
20 mM 0.2643 mL 1.3213 mL 2.6425 mL 6.6063 mL
25 mM 0.2114 mL 1.0570 mL 2.1140 mL 5.2850 mL
30 mM 0.1762 mL 0.8808 mL 1.7617 mL 4.4042 mL
40 mM 0.1321 mL 0.6606 mL 1.3213 mL 3.3031 mL
50 mM 0.1057 mL 0.5285 mL 1.0570 mL 2.6425 mL
60 mM 0.0881 mL 0.4404 mL 0.8808 mL 2.2021 mL
80 mM 0.0661 mL 0.3303 mL 0.6606 mL 1.6516 mL
100 mM 0.0529 mL 0.2643 mL 0.5285 mL 1.3213 mL
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p-Ethynylphenylalanine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p-Ethynylphenylalanine278605-15-54-Ethynyl-L-phenylalanineTryptophan HydroxylasetryptophanhydroxylaseTPHserotonin5-HT5-HIAAInhibitorinhibitorinhibit

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製品名:
p-Ethynylphenylalanine
製品番号:
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