6-Azido-hexylamine

Name: 6-Azido-hexylamine
Brand: MedChemExpress
SKU: HY-138387
Rating: 4.5 (0 reviews)

製品番号: HY-138387 純度: 98.69%: Data Sheet SDS COA 取扱説明書
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6-Azido-hexylamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 6-Azido-hexylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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6-Azido-hexylamine 構造式

CAS 番号 : 349553-73-7

容量	価格（税別）	在庫状況	数量
50 mg	$40	在庫あり	Estimated Time of Arrival: December 31
100 mg	$62	在庫あり	Estimated Time of Arrival: December 31
250 mg	$125	在庫あり	Estimated Time of Arrival: December 31
500 mg	$195	在庫あり	Estimated Time of Arrival: December 31
1 g	$312	在庫あり	Estimated Time of Arrival: December 31
5 g	$780	在庫あり	Estimated Time of Arrival: December 31
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カスタマーレビュー

Based on 0 publication(s) in Google Scholar

ADC Linker アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

6-Azido-hexylamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. 6-Azido-hexylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

Cleavable Linker

体外実験

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

142.20

分子式

C₆H₁₄N₄

CAS 番号

349553-73-7

Appearance

Liquid

Color

Colorless to light yellow

SMILES

NCCCCCCN=[N+]=[N-]

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

純度とドキュメンテーション

純度: 98.69%

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データシート (262 KB) SDS (466 KB)

COA (240 KB) HNMR (126 KB) GC (236 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]