Adarotene (Synonyms: ST1926)

Name: Adarotene
Brand: MedChemExpress
SKU: HY-14808
Rating: 5.0 (14 reviews)

製品番号: HY-14808 純度: 99.15%: Data Sheet SDS COA 取扱説明書
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Technical Support

Adarotene is an effective apoptosis inducer, which surprisingly produces DNA damage and exhibites a potent antiproliferative activity on a large panel of human tumor cells.

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CAS 番号 : 496868-77-0

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 101	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 101	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$92	在庫あり	Estimated Time of Arrival: December 31
10 mg	$172	在庫あり	Estimated Time of Arrival: December 31
50 mg	$541	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 14 publication(s) in Google Scholar

顧客検証

Cell Proliferation/Viability Assay

: Adarotene purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Aug;128:110291. [Abstract]; Western blot analysis of p-AMPKα, p-mTOR and p-P70S6K in ST1962 (2.5, 5 and 10 μM)-treated glioma cell lines for 24 h. AMPKα activation is markedly induced by ST1926 in a dose-dependent manner; phosphorylated mechanistic target of rapamycin (mTOR) and P70S6K expression levels are obviously down-regulated.

: Adarotene purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Aug;128:110291. [Abstract]; Effects of ST1926 on retinoic acid (RA) pathway. Glioma cells are treated with ST1926 (2.5, 5 and 10 μM) for 24 h, immunofluorescence staining of CRABP2.

: Adarotene purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;41(2):519-529. [Abstract]; Arithmetic means±SEM (n=10) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Adarotene (3-9 µM) or solvant DMSO alone (grey bar).

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製品説明

Adarotene is an effective apoptosis inducer, which surprisingly produces DNA damage and exhibites a potent antiproliferative activity on a large panel of human tumor cells.

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	0.12 μM Compound: 1	Antiproliferative activity against human A431 cells incubated for 24 hrs drug exposure measured after 48 hrs of recovery by sulforhodamine B assay Antiproliferative activity against human A431 cells incubated for 24 hrs drug exposure measured after 48 hrs of recovery by sulforhodamine B assay	[PMID: 22365912]
A-431	IC₅₀	0.25 μM Compound: 4	Antiproliferative effect of compound on A431 cell line expressing mutant p53 Antiproliferative effect of compound on A431 cell line expressing mutant p53	[PMID: 12620066]
A2780	IC₅₀	0.1 μM Compound: 4	Antiproliferative effect of compound on A2780/DX cell line Antiproliferative effect of compound on A2780/DX cell line	[PMID: 12620066]
COS-7	EC₅₀	0.1 μM Compound: 2	Effective concentration against retinoic acid receptor gamma in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (0.1-0.3) Effective concentration against retinoic acid receptor gamma in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (0.1-0.3)	[PMID: 16033272]
COS-7	EC₅₀	0.2 μM Compound: 2	Effective concentration against retinoic acid receptor alpha in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (0.1-0.4) Effective concentration against retinoic acid receptor alpha in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (0.1-0.4)	[PMID: 16033272]
COS-7	EC₅₀	0.2 μM Compound: 2	Effective concentration against retinoic acid receptor beta in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (0.1-0.3) Effective concentration against retinoic acid receptor beta in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (0.1-0.3)	[PMID: 16033272]
DU-145	IC₅₀	0.1 μM Compound: 4	Antiproliferative effect of compound on DU145 cell line expressing mutant p53 Antiproliferative effect of compound on DU145 cell line expressing mutant p53	[PMID: 12620066]
GBM	IC₅₀	0.18 μM Compound: 4	Antiproliferative effect of compound on GBM cell line expressing mutant p53 Antiproliferative effect of compound on GBM cell line expressing mutant p53	[PMID: 12620066]
HCT-116	IC₅₀	0.32 μM Compound: 4	Antiproliferative effect of compound on HCT116 cell line expressing wild-type p53 Antiproliferative effect of compound on HCT116 cell line expressing wild-type p53	[PMID: 12620066]
IGROV-1	IC₅₀	0.23 μM Compound: 1, ST1926	Antiproliferative activity against human IGROV1 cells after 72 hrs Antiproliferative activity against human IGROV1 cells after 72 hrs	[PMID: 17512204]
IGROV-1	IC₅₀	0.23 μM Compound: 2	Concentration of compound required for inhibition of (IGROV-1) human ovarian carcinoma cell growth by 50% Concentration of compound required for inhibition of (IGROV-1) human ovarian carcinoma cell growth by 50%	[PMID: 16033272]
IGROV-1	IC₅₀	0.23 μM Compound: 4	Antiproliferative effect of compound on IGROV-1 cell line expressing wild-type p53 Antiproliferative effect of compound on IGROV-1 cell line expressing wild-type p53	[PMID: 12620066]
IGROV-1	IC₅₀	0.4 μM Compound: 1, ST1926	Antiproliferative activity against human cisplatin-resistant IGROV1/Pt1 cells with p53 mutation after 72 hrs Antiproliferative activity against human cisplatin-resistant IGROV1/Pt1 cells with p53 mutation after 72 hrs	[PMID: 17512204]
LNCaP	IC₅₀	0.12 μM Compound: 4	Antiproliferative effect of compound on LNcaP cell line expressing wild-type p53 Antiproliferative effect of compound on LNcaP cell line expressing wild-type p53	[PMID: 12620066]
LoVo	IC₅₀	0.15 μM Compound: 4	Antiproliferative effect of compound on LoVo cell line expressing wild-type p53 Antiproliferative effect of compound on LoVo cell line expressing wild-type p53	[PMID: 12620066]
Me665/2/21	IC₅₀	0.25 μM Compound: 4	Antiproliferative effect of compound on Me665/2/21 cell line expressing mutant p53 Antiproliferative effect of compound on Me665/2/21 cell line expressing mutant p53	[PMID: 12620066]
NB-4	IC₅₀	0.082 μM Compound: 1, ST1926	Antiproliferative activity against human NB4 cells after 72 hrs Antiproliferative activity against human NB4 cells after 72 hrs	[PMID: 17512204]
NB-4	IC₅₀	0.082 μM Compound: 2	Concentration of compound required for inhibition of (NB4) human promyelocytic leukemia cell growth by 50% Concentration of compound required for inhibition of (NB4) human promyelocytic leukemia cell growth by 50%	[PMID: 16033272]
NCI-H460	IC₅₀	0.19 μM Compound: 4	Antiproliferative effect of compound on H460 cell line expressing wild-type p53 Antiproliferative effect of compound on H460 cell line expressing wild-type p53	[PMID: 12620066]
NCI-H460	IC₅₀	0.2 μM Compound: 1	Antiproliferative activity against human NCI-H460 cells incubated for 24 hrs drug exposure measured after 48 hrs of recovery by sulforhodamine B assay Antiproliferative activity against human NCI-H460 cells incubated for 24 hrs drug exposure measured after 48 hrs of recovery by sulforhodamine B assay	[PMID: 22365912]
PC-3	IC₅₀	0.21 μM Compound: 4	Antiproliferative effect of compound on PC3 cell line Antiproliferative effect of compound on PC3 cell line	[PMID: 12620066]
SAOS-2	IC₅₀	0.25 μM Compound: 4	Antiproliferative effect of compound on SAOS cell line Antiproliferative effect of compound on SAOS cell line	[PMID: 12620066]
U2OS	IC₅₀	0.26 μM Compound: 4	Antiproliferative effect of compound on U2OS cell line expressing wild-type p53 Antiproliferative effect of compound on U2OS cell line expressing wild-type p53	[PMID: 12620066]

体外実験

Adarotene causes a dose-dependent growth inhibition in a large panel of human tumor cell lines with IC₅₀ ranging from 0.1 to 0.3 μM. Adarotene causes cell accumulation in G1/S or S phase of cell cycle depending on tumor cells IGROV-1 and DU145^[1]. Adarotene is apoptotic and cytotoxic on a large spectrum of cancerous and leukemic cells, including freshly isolated AML blasts in primary culture. The molecular target of ST1926 apoptotic activity in myeloid leukemia cells is similar to the ligand-binding domain of RARγ. Adarotene treatment of cells results in rapid accumulation of intracellular calcium^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Adarotene (15, 20 mg/kg, p.o.) causes a significant tumor growth inhibition in a human ovarian carcinoma, A2780/DX, and in a human melanoma, MeWo, growing in nude mice^[1]. Adarotene (30, 40 mg/kg, p.o.) results in a significant and dose-dependent increase in the life span of NB4-bearing SCID mice without overt toxicity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

374.47

分子式

C₂₅H₂₆O₃

CAS 番号

496868-77-0

Appearance

Solid

Color

White to green

SMILES

O=C(O)/C=C/C1=CC=C(C2=CC=C(O)C(C3(C4)CC5CC4CC(C5)C3)=C2)C=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (66.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6704 mL	13.3522 mL	26.7044 mL
5 mM	0.5341 mL	2.6704 mL	5.3409 mL
10 mM	0.2670 mL	1.3352 mL	2.6704 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.68 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.68 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.15%

Select Batch:

データシート (278 KB) SDS (393 KB)

COA (253 KB) HNMR (240 KB) LCMS (95 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Cincinelli R, et al. A novel atypical retinoid endowed with proapoptotic and antitumor activity. J Med Chem. 2003 Mar 13;46(6):909-12. [Content Brief]

[2]. Garattini E, et al. ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207. [Content Brief]

細胞実験 ^[2]	Briefly, cells (1×10⁷/mL) are loaded with 1 μM FURA-2 at 37°C in the dark for 30 minutes, washed twice, resuspended in phosphate-buffered saline (PBS) containing 1.26 mM CaCl₂ at 10⁶ cells/mL and then used for the experiments. Dual excitation, alternating at 340 nm and 380 nm, is provided by a spectrophotofluorometer equipped with 2 excitation monochromators, and emission is fixed at 480 nm. The temperature is set at 37°C±1°C. In some experiments, to eliminate extracellular calcium, cells preloaded with FURA-2 are resuspended in PBS without Ca²⁺, and 0.5 mM EGTA (ethylene glycol tetraacetic acid) is added to each sample prior to addition of the appropriate stimulus. MedChemExpress (MCE) はこれらの方法の精度を確認していません。こちらは参照専用です。
動物実験 ^[2]	NB4 cells (3×10⁶) are intraperitoneally inoculated in SCID mice (8 mice/group). ST1926 is dissolved in cremophor/ethanol 1:1 solution, and diluted 1:10 in PBS at the concentration of 50 mg/kg; the doses of 30 mg/kg and 40 mg/kg are then prepared by appropriate dilutions in the same vehicle. ATRA is dissolved in the dark in Cremophor EL and kept magnetically stirred; the solution is then diluted 1:10 in PBS at the final concentration of 40 mg/kg. Both compounds are administered intraperitoneally and orally twice per day for 3 weeks starting from the day after cell inoculation, in a volume of 10 mL/kg. During treatments body weight and lethality are registered. MedChemExpress (MCE) はこれらの方法の精度を確認していません。こちらは参照専用です。
参考文献	[1]. Cincinelli R, et al. A novel atypical retinoid endowed with proapoptotic and antitumor activity. J Med Chem. 2003 Mar 13;46(6):909-12. [Content Brief] [2]. Garattini E, et al. ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6704 mL	13.3522 mL	26.7044 mL	66.7610 mL
	5 mM	0.5341 mL	2.6704 mL	5.3409 mL	13.3522 mL
	10 mM	0.2670 mL	1.3352 mL	2.6704 mL	6.6761 mL
	15 mM	0.1780 mL	0.8901 mL	1.7803 mL	4.4507 mL
	20 mM	0.1335 mL	0.6676 mL	1.3352 mL	3.3381 mL
	25 mM	0.1068 mL	0.5341 mL	1.0682 mL	2.6704 mL
	30 mM	0.0890 mL	0.4451 mL	0.8901 mL	2.2254 mL
	40 mM	0.0668 mL	0.3338 mL	0.6676 mL	1.6690 mL
	50 mM	0.0534 mL	0.2670 mL	0.5341 mL	1.3352 mL
	60 mM	0.0445 mL	0.2225 mL	0.4451 mL	1.1127 mL

Adarotene Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adarotene496868-77-0ST1926ST 1926ST-1926ApoptosisInhibitorinhibitorinhibit

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Adarotene (Synonyms: ST1926)

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Adarotene 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

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純度とドキュメンテーション

参考文献

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Adarotene 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Adarotene Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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