2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. Afegostat

Afegostat  (Synonyms: D-Isofagomine; Isofagomine)

製品番号: HY-14829 純度: 99.83%
COA 取扱説明書 Technical Support

Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.

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Afegostat

Afegostat 構造式

CAS 番号 : 169105-89-9

容量 価格（税別） 在庫状況 数量
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 731 在庫あり
Solution
10 mM * 1 mL in Water USD 731 在庫あり
Oil
1 mg $190 在庫あり
5 mg $665 在庫あり
10 mg $1100 在庫あり
25 mg $2350 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

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Other Forms of Afegostat:

Afegostat 関連抗体

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製品説明

Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].

IC50 & Target

GCase[1]
Cellular Effect
Cell Line Type Value Description References
Hepatocyte IC50
2 μM
Compound: 7, D-IFG
Inhibition of glucagon-stimulated glycogen degradation in hepatocytes
Inhibition of glucagon-stimulated glycogen degradation in hepatocytes
[PMID: 18595718]
Hepatocyte IC50
2 μM
Compound: 9
Inhibition of glucagon-stimulated glycogen degradation in hepatocytes
Inhibition of glucagon-stimulated glycogen degradation in hepatocytes
[PMID: 16970395]
Hepatocyte IC50
3 μM
Compound: 7, D-IFG
Inhibition of basal glycogen degradation in hepatocytes
Inhibition of basal glycogen degradation in hepatocytes
[PMID: 18595718]
Hepatocyte IC50
3 μM
Compound: 9
Inhibition of glycogen degradation in hepatocytes
Inhibition of glycogen degradation in hepatocytes
[PMID: 16970395]
体内実験

Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

147.17

分子式

C6H13NO3
CAS 番号
Appearance

Oil

Color

Colorless to light yellow

SMILES

O[C@@H]1CNC[C@H](CO)[C@H]1O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Pure form -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 4.17 mg/mL (28.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7949 mL 33.9743 mL 67.9486 mL
5 mM 1.3590 mL 6.7949 mL 13.5897 mL
10 mM 0.6795 mL 3.3974 mL 6.7949 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.96%

COA (248 KB) HNMR (225 KB) RP-HPLC (242 KB) MS (69 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.7949 mL 33.9743 mL 67.9486 mL 169.8716 mL
5 mM 1.3590 mL 6.7949 mL 13.5897 mL 33.9743 mL
10 mM 0.6795 mL 3.3974 mL 6.7949 mL 16.9872 mL
15 mM 0.4530 mL 2.2650 mL 4.5299 mL 11.3248 mL
20 mM 0.3397 mL 1.6987 mL 3.3974 mL 8.4936 mL
25 mM 0.2718 mL 1.3590 mL 2.7179 mL 6.7949 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Afegostat Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Afegostat169105-89-9D-Isofagomine IsofagomineGlycosidaseInhibitorinhibitorinhibit

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