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Afegostat D-Tartrate (Synonyms: D-Isofagomine (D-Tartrate); Isofagomine (D-Tartrate))

Cat. No.: HY-14829E
Handling Instructions

Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.

For research use only. We do not sell to patients.

Afegostat D-Tartrate Chemical Structure

Afegostat D-Tartrate Chemical Structure

CAS No. : 957230-65-8

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Description

Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].

IC50 & Target

GCase[1]

In Vivo

Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1].

Clinical Trial
Molecular Weight

297.26

Formula

C₁₀H₁₉NO₉

CAS No.

957230-65-8

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Afegostat D-Tartrate
Cat. No.:
HY-14829E
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