Afegostat
Based on 1 Customer Validation
Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 169105-89-9
- Formula: C6H13NO3
- Molecular Weight:147.17
-
Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
GCase[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | IC50 |
2 μM
Compound: 7, D-IFG
|
Inhibition of glucagon-stimulated glycogen degradation in hepatocytes
Inhibition of glucagon-stimulated glycogen degradation in hepatocytes
|
[PMID: 18595718] |
| Hepatocyte | IC50 |
2 μM
Compound: 9
|
Inhibition of glucagon-stimulated glycogen degradation in hepatocytes
Inhibition of glucagon-stimulated glycogen degradation in hepatocytes
|
[PMID: 16970395] |
| Hepatocyte | IC50 |
3 μM
Compound: 7, D-IFG
|
Inhibition of basal glycogen degradation in hepatocytes
Inhibition of basal glycogen degradation in hepatocytes
|
[PMID: 18595718] |
| Hepatocyte | IC50 |
3 μM
Compound: 9
|
Inhibition of glycogen degradation in hepatocytes
Inhibition of glycogen degradation in hepatocytes
|
[PMID: 16970395] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 169105-89-9
-
Appearance Oil
-
Molecular Weight 147.17
-
Formula C6H13NO3
-
Color Colorless to light yellow
-
SMILES
O[C@@H]1CNC[C@H](CO)[C@H]1O
-
Synonyms
D-Isofagomine; Isofagomine
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 4.17 mg/mL (28.33 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.7949 mL | 33.9743 mL | 67.9486 mL | 169.8716 mL |
| 5 mM | 1.3590 mL | 6.7949 mL | 13.5897 mL | 33.9743 mL | |
| 10 mM | 0.6795 mL | 3.3974 mL | 6.7949 mL | 16.9872 mL | |
| 15 mM | 0.4530 mL | 2.2650 mL | 4.5299 mL | 11.3248 mL | |
| 20 mM | 0.3397 mL | 1.6987 mL | 3.3974 mL | 8.4936 mL | |
| 25 mM | 0.2718 mL | 1.3590 mL | 2.7179 mL | 6.7949 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Afegostat Related Classifications
HY-14829 Related Classifications
Powered by Bioz