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Afegostat (Synonyms: D-Isofagomine; Isofagomine)

Cat. No.: HY-14829
Handling Instructions

Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.

For research use only. We do not sell to patients.

Afegostat Chemical Structure

Afegostat Chemical Structure

CAS No. : 169105-89-9

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Other Forms of Afegostat:

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Description

Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].

IC50 & Target

GCase[1]

In Vivo

Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1].

Clinical Trial
References
Molecular Weight

147.17

Formula

C₆H₁₃NO₃

CAS No.

169105-89-9

SMILES

O[[email protected]@H]1CNC[[email protected]](CO)[[email protected]]1O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Afegostat
Cat. No.:
HY-14829
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Afegostat

Cat. No.: HY-14829