Afegostat hydrochloride
Afegostat hydrochloride (D-Isofagomine hydrochloride) is a potent β-galactosidase inhibitor with activity ameliorating GM1-gangliosidosis and Morquio B disease-associated mutations. Afegostat hydrochloride is able to induce the maturation of mutant β-galactosidase in fibroblasts from patients with GM1-gangliosidosis. Afegostat hydrochloride also promotes the reduction of keratin sulfate and oligosaccharide load in patient cells.
For research use only. We do not sell to patients.
- CAS No.: 161302-93-8
- Formula: C6H14ClNO3
- Molecular Weight:183.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 161302-93-8
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Molecular Weight 183.63
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Formula C6H14ClNO3
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SMILES
OC[C@@H]1[C@H]([C@@H](CNC1)O)O.Cl
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Synonyms
D-Isofagomine hydrochloride; Isofagomine hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11(4):840-56. [Content Brief]
[2]. 4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Afegostat hydrochloride Related Classifications
HY-14829A Related Classifications
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