1. Cell Cycle/DNA Damage
    Epigenetics
    Anti-infection
  2. PARP
    Influenza Virus
  3. Iniparib

Iniparib (Synonyms: BSI-201; NSC-746045; IND-71677)

Cat. No.: HY-12015 Purity: 99.87%
Handling Instructions

Iniparib (BSI-201) is an irreversible inhibitor of PARP1, used in the research of triple negative breast cancer.

For research use only. We do not sell to patients.

Iniparib Chemical Structure

Iniparib Chemical Structure

CAS No. : 160003-66-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
50 mg USD 300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 420 In-stock
Estimated Time of Arrival: December 31
200 mg USD 780 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

Iniparib (BSI-201) is an irreversible inhibitor of PARP1, used in the research of triple negative breast cancer.

IC50 & Target[3]

PARP1

 

In Vitro

Iniparib nonselectively modifies cysteine-containing proteins in tumor cells[1]. Iniparib (100 μM) weakly inhibits SSB repair, and the inhibition can be reversed by knockdown of PARP1[2]. Iniparib in combination with cisplatin is cytotoxic to Myc/MDA-231 with EMT changes[3].

Clinical Trial
Molecular Weight

292.03

Formula

C₇H₅IN₂O₃

CAS No.

160003-66-7

SMILES

O=C(C1=CC=C(C([N+]([O-])=O)=C1)I)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (342.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4243 mL 17.1215 mL 34.2431 mL
5 mM 0.6849 mL 3.4243 mL 6.8486 mL
10 mM 0.3424 mL 1.7122 mL 3.4243 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.56 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

For nine day cell proliferation assay, MDA-MB-436 and MDA-MB-231 cells are plated at 2000 and 500 cells/well respectively in a 96-well plate and treated with veliparib, cmpd-A, cmpd-C, Iniparib or Iniparib-met at 0, 0.0001, 0.01,0.1, 1 or 10 μM for nine days. For five day cell proliferation assay, MDAMB-231 and MDA-MB-436 cells are plated at 1000 and 4000 cells/well respectively in a 96-well plate and treated with Iniparib or Iniparib-met at 0. 0.1, 0.3, 1, 3 or 10 μM in the presence of 0, 1.8, 3.75, or 7.5 µM BSO for 5 days. DLD1+/+ and DLD1-/- cells are plated at 1000 cells/well in a 96-well plate and treated with TMZ at 0, 0.003, 0.01, 0.03, 0.1, 0.3 or 1 mM in the presence of 0, 0.005, 0.05, 0.5, or 5 µM veliparib, or Iniparib for five days. After treatment, cell titer glow is carried out[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.87%

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Keywords:

IniparibBSI-201NSC-746045IND-71677BSI201BSI 201NSC746045NSC 746045IND71677IND 71677PARPInfluenza Viruspoly ADP ribose polymeraseInhibitorinhibitorinhibit

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Product name:
Iniparib
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HY-12015
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