2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Calyculin A

Calyculin A  (Synonyms: (-)-Calyculin A)

Art. -Nr.: HY-18983 Reinheit: 98%
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SDS
Handling Instructions Technical Support

Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively.

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Calyculin A

Calyculin A Chemische Struktur

CAS. Nr. : 101932-71-2

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Based on 19 publication(s) in Google Scholar

Calyculin A Spezialitätsempfehlungen:

Calyculin A Related Antibodies

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Beschreibung

Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively[1].

IC50 & Target

IC50: 2 nM (PP1); 0.5-1 nM (PP2A)[1]
In Vitro

Calyculin A (1-10 nM; 24 hours) induces cytotoxicity in MG63 cells in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Calyculin A Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: Human osteosarcoma MG63 cells
Concentration: 0, 1, 2, 5, 10 nM
Incubation Time: 24 hours
Result: Treatment with 0.1 nM for 24 h had a minimal effect on MG63 cell survival. Cell rounding and shrinking were obvious in the cultures treated for 24 h with 5 nM. The level of the cell viability treated with 10 nM was 27% that of the control cultures.
Molekulargewicht

1009.17

Formel

C50H81N4O15P
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]([C@H]([C@@H](N(C)C)COC)O)C(NCC[C@@H](C1=NC(/C=C/C[C@@H]([C@@H](C)[C@H](O)C2)O[C@@]32C(C)(C)[C@@H](OP(O)(O)=O)[C@@H]([C@@H](OC)C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C(C)=C/C=C/C(C)=C\C#N)O3)=CO1)C)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Reinheit & Dokumentation

Purity: 99.67%

SDS (480 KB)

COA (250 KB) RP-HPLC (135 KB)

Handling Instructions (2659 KB)
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Calyculin A Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Calyculin A101932-71-2(-)-Calyculin APhosphataseInhibitorinhibitorinhibit

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