Clenbuterol hydrochloride (Synonyms: NAB-365 hydrochloride)

Name: Clenbuterol hydrochloride
Brand: MedChemExpress
SKU: HY-B1614
Rating: 5.0 (6 reviews)

Art. -Nr.: HY-B1614 Reinheit: 99.94%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage.

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Clenbuterol hydrochloride Chemische Struktur

CAS. Nr. : 21898-19-1

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
200 mg	Angebot einholen
500 mg	Angebot einholen

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Based on 6 publication(s) in Google Scholar

Other Forms of Clenbuterol hydrochloride:

Clenbuterol Angebot einholen
Clenbuterol hydrochloride (Standard) Angebot einholen

6 Publications Citing Use of MCE Clenbuterol hydrochloride

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

α adrenergic receptor β adrenergic receptor

Biologische Aktivität
Protokoll
Reinheit & Dokumentation
Verweise
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Beschreibung

In Vitro

Clenbuterol increases lipolysis in rat primary adipocytes compared with control. Free glycerol release into the culture medium is 158% and 190% of control values in cultures containing 0.1, or 1 μM Clenbuterol, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Clenbuterol (0.01-0.5 mg/kg; i.p.; male Long-Evans rats) hydrochloride reduces the cortical infarct volume in Long-Evans rats as measured 7 days after permanent occlusion of the middle cerebral artery^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

313.65

Formel

C₁₂H₁₉Cl₃N₂O

CAS. Nr.

21898-19-1

Appearance

Solid

Color

White to off-white

SMILES

OC(CNC(C)(C)C)C1=CC(Cl)=C(N)C(Cl)=C1.[H]Cl

Structure Classification

Others

Initial Source

Endogenous metabolite

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 83.33 mg/mL (265.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1883 mL	15.9413 mL	31.8827 mL
5 mM	0.6377 mL	3.1883 mL	6.3765 mL
10 mM	0.3188 mL	1.5941 mL	3.1883 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.98%

Select Batch:

Data Sheet (275 KB) SDS (480 KB)

COA (248 KB) HNMR (272 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

Verweise

[1]. O'Donnell JM, et al. Effects of clenbuterol and antidepressant drugs on beta adrenergic receptor/N-protein coupling in the cerebral cortex of the rat.J PharmacolExpTher. 1985 Jul;234(1):30-6. [Content Brief]

[2]. Culmsee C, Stumm RK, Schäfer MK, Weihe E, Krieglstein J. Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage. Eur J Pharmacol. 1999;379(1):33-45. [Content Brief]

[3]. Kim J, t al. The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility. Proc Natl Acad Sci U S A. 2020;117(22):12435-12443. [Content Brief]

Zellassay ^[1]	MTS assay is performed to determine the number of viable cells in culture. Cells are treated with 0 (vehicle only), 0.1, or 1 μM Clenbuterol for 6, 12, 24, or 48 h. The absorbance is measured at 490 nm in a plate reader determine the formazan concentration, which is proportional to the number of living cells in culture^[1]. MCE hat die Genauigkeit dieser Methoden nicht unabhängig bestätigt. Sie dienen nur als Referenz.
Tierverwaltung ^[2]	Rats: Rats are randomly divided into two treatment groups. The control group is provided with standard chow and water ad libitum for 3 weeks, while the Clenbuterol group is provided with standard chow and treated for 3 weeks with Clenbuterol administered via the drinking water (30 mg Clenbuterol/L). Body weight and the amount of water consumed are recorded twice each week. After 3 wk, the animals are anesthetized and hindlimb muscles are excised^[2]. MCE hat die Genauigkeit dieser Methoden nicht unabhängig bestätigt. Sie dienen nur als Referenz.
Verweise	[1]. O'Donnell JM, et al. Effects of clenbuterol and antidepressant drugs on beta adrenergic receptor/N-protein coupling in the cerebral cortex of the rat.J PharmacolExpTher. 1985 Jul;234(1):30-6. [Content Brief] [2]. Culmsee C, Stumm RK, Schäfer MK, Weihe E, Krieglstein J. Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage. Eur J Pharmacol. 1999;379(1):33-45. [Content Brief] [3]. Kim J, t al. The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility. Proc Natl Acad Sci U S A. 2020;117(22):12435-12443. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1883 mL	15.9413 mL	31.8827 mL	79.7067 mL
	5 mM	0.6377 mL	3.1883 mL	6.3765 mL	15.9413 mL
	10 mM	0.3188 mL	1.5941 mL	3.1883 mL	7.9707 mL
	15 mM	0.2126 mL	1.0628 mL	2.1255 mL	5.3138 mL
	20 mM	0.1594 mL	0.7971 mL	1.5941 mL	3.9853 mL
	25 mM	0.1275 mL	0.6377 mL	1.2753 mL	3.1883 mL
	30 mM	0.1063 mL	0.5314 mL	1.0628 mL	2.6569 mL
	40 mM	0.0797 mL	0.3985 mL	0.7971 mL	1.9927 mL
	50 mM	0.0638 mL	0.3188 mL	0.6377 mL	1.5941 mL
	60 mM	0.0531 mL	0.2657 mL	0.5314 mL	1.3284 mL
	80 mM	0.0399 mL	0.1993 mL	0.3985 mL	0.9963 mL
	100 mM	0.0319 mL	0.1594 mL	0.3188 mL	0.7971 mL

Clenbuterol hydrochloride Related Classifications

Metabolic Disease Inflammation/Immunology Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clenbuterol21898-19-1NAB-365NAB365NAB 365Adrenergic ReceptorBeta ReceptorastrocytesischemicdamageskeletalmusclestrengthhypertrophyInhibitorinhibitorinhibit

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Clenbuterol hydrochloride (Synonyms: NAB-365 hydrochloride)

Kundenbewertung

Other Forms of Clenbuterol hydrochloride:

Clenbuterol hydrochloride Related Antibodies

6 Publications Citing Use of MCE Clenbuterol hydrochloride

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Protokoll

Reinheit & Dokumentation

Verweise

Kundenbewertung

Clenbuterol hydrochloride Related Antibodies

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

Clenbuterol hydrochloride Related Classifications

Keywords:

Ihre kürzlich angesehenen Produkte:

Kundenbewertung

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SAFETY DATA SHEET (SDS)

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