Durlobactam sodium (Synonyms: ETX2514)

Name: Durlobactam sodium
Brand: MedChemExpress
SKU: HY-117974
Rating: 5.0 (6 reviews)

Cat. No.: HY-117974 Purity: 99.62%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Durlobactam sodium salt (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC₅₀s of 4, 14 and 190 nM for Class A KPC-2, Class C AmpC and Class D OXA-24, respectively. For the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.

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Durlobactam sodium 화학구조

CAS No. : 1467157-21-6

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 6 publication(s) in Google Scholar

6 Publications Citing Use of MCE Durlobactam sodium

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

IC50: 4 nM (Class A KPC-2), 14 nM (Class C AmpC), 190 nM (Class D OXA-24)^[1].

In Vitro

Durlobactam sodium salt (ETX2514) inhibits against OXA-24/40 and OXA-23 from A. baumannii strains with MICs of 4 μg/mL and 2 μg/mL, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Durlobactam sodium salt (ETX2514) (50 mg/kg, 200 mg/kg; sc; single dose) effectively inhibits Acinetobacter baumannii in a neutropenic mouse thigh infection model (mice carrying blaTEM-1, blaADC-82, blaOXA-23, and blaOXA-66)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

분자량

299.24

화학식

C₈H₁₀N₃NaO₆S

CAS No.

1467157-21-6

Appearance

Solid

Color

White to light yellow

SMILES

NC([C@H]1[N@@]2C(N([C@H](C=C1C)C2)OS(=O)(O[Na])=O)=O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

H₂O : ≥ 100 mg/mL (334.18 mM)

DMSO : 50 mg/mL (167.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3418 mL	16.7090 mL	33.4180 mL
5 mM	0.6684 mL	3.3418 mL	6.6836 mL
10 mM	0.3342 mL	1.6709 mL	3.3418 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.62%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (254 KB) HNMR (257 KB) RP-HPLC (254 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Durand-Réville TF, et al. ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. Nat Microbiol. 2017 Jun 30;2:17104. [Content Brief]

[2]. González-Bello C. Recently developed synthetic compounds with anti-infective activity. Curr Opin Pharmacol. 2019 Oct;48:17-23. [Content Brief]

[3]. Barnes MD, et al. Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent. mBio. 2019 Mar 12;10(2):e00159-19. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	3.3418 mL	16.7090 mL	33.4180 mL	83.5450 mL
	5 mM	0.6684 mL	3.3418 mL	6.6836 mL	16.7090 mL
	10 mM	0.3342 mL	1.6709 mL	3.3418 mL	8.3545 mL
	15 mM	0.2228 mL	1.1139 mL	2.2279 mL	5.5697 mL
	20 mM	0.1671 mL	0.8354 mL	1.6709 mL	4.1772 mL
	25 mM	0.1337 mL	0.6684 mL	1.3367 mL	3.3418 mL
	30 mM	0.1114 mL	0.5570 mL	1.1139 mL	2.7848 mL
	40 mM	0.0835 mL	0.4177 mL	0.8354 mL	2.0886 mL
	50 mM	0.0668 mL	0.3342 mL	0.6684 mL	1.6709 mL
	60 mM	0.0557 mL	0.2785 mL	0.5570 mL	1.3924 mL
	80 mM	0.0418 mL	0.2089 mL	0.4177 mL	1.0443 mL
	100 mM	0.0334 mL	0.1671 mL	0.3342 mL	0.8354 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Durlobactam sodium Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Durlobactam1467157-21-6ETX2514ETX 2514ETX-2514BacterialInhibitorinhibitorinhibit

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Durlobactam sodium (Synonyms: ETX2514)

고객리뷰

Durlobactam sodium Related Antibodies

6 Publications Citing Use of MCE Durlobactam sodium

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

Durlobactam sodium Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Durlobactam sodium Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report