2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. Eledoisin Related Peptide

Eledoisin Related Peptide  (Synonyms: Eledoisin-Related Peptide; Eledoisin RP)

Cat. No.: HY-P1186 Purity: 99.55%
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Eledoisin Related Peptide is a Substance P analog that excites neurons and triggers behavioral responses. Eledoisin Related Peptide is also a tachykinin receptor ligand.

For research use only. We do not sell to patients.

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Eledoisin Related Peptide

Eledoisin Related Peptide Chemical Structure

CAS No. : 2990-43-4

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Based on 1 publication(s) in Google Scholar

Eledoisin Related Peptide Related Antibodies

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  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Eledoisin Related Peptide is a Substance P analog that excites neurons and triggers behavioral responses. Eledoisin Related Peptide is also a tachykinin receptor ligand.

IC50 & Target

Tachykinin receptor[1]
In Vivo

Eledoisin Related Peptide shares with Substance P (SP) a common N-terminal amino acid sequence and has been shown by to have SP-like activity in the periphery (gut and salivary glands) and the CNS. Eledoisin-related peptide seems to be roughly equipotent with Substance P at identical ejection currents on the single-cell activity of neurons in this nucleus[2]. Both glutamate and substance P (and its analogue, eledoisin-related peptide) have excitatory effects on the activity of respiratory neurons and reflex interneurons[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

706.94

Formula

C34H58N8O6S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Lys-Phe-Ile-Gly-Leu-Met-NH2
Sequence Shortening

KFIGLM-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (141.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4145 mL 7.0727 mL 14.1455 mL
5 mM 0.2829 mL 1.4145 mL 2.8291 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Animal Administration
[2]

Rats[2]

Twenty-two male albino rats (230-260 g) are anesthetized with chloral hydrate (400 mg/kg, i.p.) and prepared for recording. Briefly, a singlebarrel recording pipette (tip 1 μm) is glued alongside a conventional five-barrel micropipette (tip 15-25/μm) then filled with 2 M NaCI saturated with Fast Green (impedance 4-7 M). The distance between the tip of the recording electrode and that of the five-barrel micropipette is 15-25/zm. Fast Green is ejected at the end of the experiment to identify the recording site. One side barrel of the five-barrel micropipette is loaded with 4 M NaCI for automatic current balancing and the others with three of the following solutions: L-epinephrine bitartrate (0. l M, pH 4.0), L-norepinephrine bitartrate (0.1 M, pH 4.0), Substance P (2.75 mM), physalaemin (2.6 mM), substance P 4-11 octapeptide (3.1 mM), eledoisin-related peptide (20 mM), neurotensin, bradykinin triacetate (15 mM), met-enkephalin (6.5 mM), TRH (48 mM). Spontaneously active cells are recorded in the locus coeruleus or in the nearby mesencephalic nucleus of the fifth nerve whose cells are easily identified by their increased activity upon manipulation of the jaw[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4145 mL 7.0727 mL 14.1455 mL 35.3637 mL
5 mM 0.2829 mL 1.4145 mL 2.8291 mL 7.0727 mL
10 mM 0.1415 mL 0.7073 mL 1.4145 mL 3.5364 mL
15 mM 0.0943 mL 0.4715 mL 0.9430 mL 2.3576 mL
20 mM 0.0707 mL 0.3536 mL 0.7073 mL 1.7682 mL
25 mM 0.0566 mL 0.2829 mL 0.5658 mL 1.4145 mL
30 mM 0.0472 mL 0.2358 mL 0.4715 mL 1.1788 mL
40 mM 0.0354 mL 0.1768 mL 0.3536 mL 0.8841 mL
50 mM 0.0283 mL 0.1415 mL 0.2829 mL 0.7073 mL
60 mM 0.0236 mL 0.1179 mL 0.2358 mL 0.5894 mL
80 mM 0.0177 mL 0.0884 mL 0.1768 mL 0.4420 mL
100 mM 0.0141 mL 0.0707 mL 0.1415 mL 0.3536 mL
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Eledoisin Related Peptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eledoisin Related Peptide2990-43-4Eledoisin-Related Peptide Eledoisin RPNeurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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