Flumorph (Synonyms: SYP-L190)

製品番号: HY-17521 純度: 99.57%: Data Sheet SDS COA 取扱説明書
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Flumorph (SYP-L190) is a carboxylic acid amide fungicide. Flumorph inhibits the polar growth of Phytophthora melonis by disrupting the arrangement of filamentous actin. Flumorph can be used to study Phytophthora melonis infection.

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Flumorph 構造式

CAS 番号 : 211867-47-9

容量	価格（税別）	在庫状況	数量
5 mg	$40	在庫あり	Estimated Time of Arrival: December 31
10 mg	$64	在庫あり	Estimated Time of Arrival: December 31
25 mg	$123	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other Forms of Flumorph:

Flumorph (Standard) お問い合わせ

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生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体外実験

Flumorph (0.01-25 mg/liter; 0-4 days) inhibits mycelial growth, sporangiospore germination, and disrupts the polar deposition of newly synthesized cell wall components (leading to sustained isodiametric growth and spore swelling) in the sensitive strain TJ-58 of Phytophthora melonis^[1].
Flumorph (0-25 mg/liter; 0-8 h) disrupts the apical growth of hyphae from the sensitive strain TJ-58 of Phytophthora melonis, induces periodic swelling with ectopic cell wall deposition, and disrupts the F-actin structure^[1].
Flumorph (25 mg/liter; 8, 16, 24 h) induces extensive cell wall thickening in hyphae of the sensitive strain TJ-58 of Phytophthora melonis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

371.40

分子式

C₂₁H₂₂FNO₄

CAS 番号

211867-47-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCOCC1)/C=C(C2=CC=C(OC)C(OC)=C2)\C3=CC=C(F)C=C3

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (269.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6925 mL	13.4626 mL	26.9251 mL
5 mM	0.5385 mL	2.6925 mL	5.3850 mL
10 mM	0.2693 mL	1.3463 mL	2.6925 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.57%

Select Batch:

データシート (273 KB) SDS (251 KB)

COA (250 KB) HNMR (239 KB) LCMS (93 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Sheng Zhu S, et al. Flumorph Is a Novel Fungicide That Disrupts Microfilament Organization in Phytophthora melonis. Phytopathology. 2007;97(5):643-649. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6925 mL	13.4626 mL	26.9251 mL	67.3129 mL
	5 mM	0.5385 mL	2.6925 mL	5.3850 mL	13.4626 mL
	10 mM	0.2693 mL	1.3463 mL	2.6925 mL	6.7313 mL
	15 mM	0.1795 mL	0.8975 mL	1.7950 mL	4.4875 mL
	20 mM	0.1346 mL	0.6731 mL	1.3463 mL	3.3656 mL
	25 mM	0.1077 mL	0.5385 mL	1.0770 mL	2.6925 mL
	30 mM	0.0898 mL	0.4488 mL	0.8975 mL	2.2438 mL
	40 mM	0.0673 mL	0.3366 mL	0.6731 mL	1.6828 mL
	50 mM	0.0539 mL	0.2693 mL	0.5385 mL	1.3463 mL
	60 mM	0.0449 mL	0.2244 mL	0.4488 mL	1.1219 mL
	80 mM	0.0337 mL	0.1683 mL	0.3366 mL	0.8414 mL
	100 mM	0.0269 mL	0.1346 mL	0.2693 mL	0.6731 mL

Flumorph Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flumorph211867-47-9SYP-L190FungalfungicidePhytophthora melonisInhibitorinhibitorinhibit

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