1. Apoptosis Autophagy
  2. Apoptosis Autophagy
  3. Glycitein

Glycitein  (Synonyms: Glycetein)

Cat. No.: HY-N0016 Purity: 98.03%
COA Handling Instructions

Glycitein is a soy isoflavone used to study apoptosis and antioxidant.

For research use only. We do not sell to patients.

Glycitein Chemical Structure

Glycitein Chemical Structure

CAS No. : 40957-83-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 194 In-stock
Solution
10 mM * 1 mL in DMSO USD 194 In-stock
Solid
1 mg USD 35 In-stock
5 mg USD 75 In-stock
10 mg USD 120 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Glycitein:

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  • Biological Activity

  • Purity & Documentation

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Description

Glycitein is a soy isoflavone used to study apoptosis and antioxidant[1][2][3].

In Vitro

Glycitein (0-30 μM, 4 days/20 h) inhibits the dextran-coated charcoal/fetal bovine serum (DDC-FBS)-induced growth (4 days) and DNA synthesis (20 h) of aortic smooth muscle cells (SMC) from stroke-prone spontaneously hypertensive rats (SHRSP)[3].
Glycitein (0-100 μM, 24 h) inhibits the viability in human gastric cancer cells, induces apoptosis and induces G0/G1 phase arrest[4].
Glycitein (100 μg/mL, 2 days) protects against Aβ-induced toxicity and oxidative stress in transgenic C. elegans[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[4]

Cell Line: human gastric cancer cells (AGS, MKN-28, MKN-45, NCI-N87, YCC-1, YCC-6, SNU-5, SNU-216, SNU-484, SNU-668)
Concentration: 24 h
Incubation Time: 0-100 μM
Result: IC50: 30.98, 60.17, 35.07, 36.05, 33.11, 88.62, 97.68, 83.02, 46.87, 87.55 μM respectively.

Apoptosis Analysis[4]

Cell Line: AGS cells
Concentration: 30 μM
Incubation Time: 3, 6, 12, and 24 hr
Result: Increased the expression of Bax, Caspase-3 and cleaved PARP protein, and decreased levels of Bcl-2.
Increased the fluorescence intensity of PI staining.
In Vivo

Glycitein (3 mg/day, oral gavage, 4 days) has weak estrogenic activity, and increases uterine weight in weaning female B6D2F1 mice[1].
Glycitein (15, 30, or 45 mg/kg in diet) in sows during late pregnancy and lactation enhances antioxidative indices, decreases the content of MDA in sow's plasma and milk, improves milk composition, and enhancesthe growth performance of the sucking piglets[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

284.26

Formula

C16H12O5

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C1=CC=C(O)C=C1)=CO2)C3=C2C=C(O)C(OC)=C3

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (87.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
10 mM 0.3518 mL 1.7590 mL 3.5179 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (8.79 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (8.79 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Glycitein Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Glycitein
Cat. No.:
HY-N0016
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