H-Val-Pro-Pro-OH TFA

Name: H-Val-Pro-Pro-OH TFA
Brand: MedChemExpress
SKU: HY-114161A
Rating: 4.5 (1 reviews)

製品番号: HY-114161A 純度: 98.0%: Data Sheet SDS COA 取扱説明書
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H-Val-Pro-Pro-OH (TFA), a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC₅₀ of 9 μM.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

カスタムペプチド

H-Val-Pro-Pro-OH TFA 構造式

CAS 番号 : 2828433-08-3

容量	価格（税別）	在庫状況	数量
5 mg	$50	在庫あり	Estimated Time of Arrival: December 31
10 mg	$70	在庫あり	Estimated Time of Arrival: December 31
25 mg	$120	在庫あり	Estimated Time of Arrival: December 31
50 mg	$190	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of H-Val-Pro-Pro-OH TFA:

H-Val-Pro-Pro-OH 在庫あり

顧客検証

•Int J Pharm. 2024 Apr 25:655:124055. [Abstract]

Angiotensin Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

AT1 Receptor AT2 Receptor

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

H-Val-Pro-Pro-OH (TFA), a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC₅₀ of 9 μM.

IC₅₀ & Target

IC50: 9 μM (ACE)^[1].

体外実験

H-Val-Pro-Pro-OH (TFA), a proline peptides derivative, could inhibit Angiotensin I converting enzyme (ACE), with an IC₅₀ of 9 μM^[1]. H-Val-Pro-Pro-OH (TFA) could enhance insulin sensitivity and prevent insulin resistance in 3T3-F442A pre-adipocytes. H-Val-Pro-Pro-OH (TFA) also has anti-hypertensive and anti-inflammatory functions. H-Val-Pro-Pro-OH (TFA) further enhances the expression of glucose transporter 4 (GLUT4) in adipocytes and restores glucose uptake in TNF-treated adipocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

425.40

分子式

C₁₇H₂₆F₃N₃O₆

CAS 番号

2828433-08-3

Appearance

Solid

Color

White to off-white

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Sealed storage, away from moisture
Powder	-80°C	2 years
	-20°C	1 year
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

H₂O : 125 mg/mL (293.84 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3507 mL	11.7536 mL	23.5073 mL
5 mM	0.4701 mL	2.3507 mL	4.7015 mL
10 mM	0.2351 mL	1.1754 mL	2.3507 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 25 mg/mL (58.77 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 98.0%

Select Batch:

データシート (274 KB) SDS (252 KB)

COA (249 KB) HNMR (297 KB) MS (69 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83. [Content Brief]

[2]. Chakrabarti S, et al. Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Preadipocytes. J Agric Food Chem. 2018 Oct 3;66(39):10179-10187. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.3507 mL	11.7536 mL	23.5073 mL	58.7682 mL
	5 mM	0.4701 mL	2.3507 mL	4.7015 mL	11.7536 mL
	10 mM	0.2351 mL	1.1754 mL	2.3507 mL	5.8768 mL
	15 mM	0.1567 mL	0.7836 mL	1.5672 mL	3.9179 mL
	20 mM	0.1175 mL	0.5877 mL	1.1754 mL	2.9384 mL
	25 mM	0.0940 mL	0.4701 mL	0.9403 mL	2.3507 mL
	30 mM	0.0784 mL	0.3918 mL	0.7836 mL	1.9589 mL
	40 mM	0.0588 mL	0.2938 mL	0.5877 mL	1.4692 mL
	50 mM	0.0470 mL	0.2351 mL	0.4701 mL	1.1754 mL
	60 mM	0.0392 mL	0.1959 mL	0.3918 mL	0.9795 mL
	80 mM	0.0294 mL	0.1469 mL	0.2938 mL	0.7346 mL
	100 mM	0.0235 mL	0.1175 mL	0.2351 mL	0.5877 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.