1. Others
  2. Others

LCL521 dihydrochloride (Synonyms: 1,3DMG-B13 dihydrochloride)

Cat. No.: HY-103593A
Handling Instructions

LCL521 dihydrochloride (1,3DMG-B13 dihydrochloride) is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase).

For research use only. We do not sell to patients.

LCL521 dihydrochloride Chemical Structure

LCL521 dihydrochloride Chemical Structure

CAS No. : 1226759-47-2

Size Stock
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Customer Review

Other Forms of LCL521 dihydrochloride:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

LCL521 dihydrochloride (1,3DMG-B13 dihydrochloride) is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase).

IC50 & Target

ACDase, ASMase[1]

In Vitro

LCL521 (1 µM) acts as a potent inhibitor of cellular ACDase activity, whereas 10 µM LCL521 has an additional, decreased affect on the α-form of this enzyme. LCL521 (10µM) causes a time-dependent (1 hours and 5 hours) decrease of the α-ACDase form in MCF7 cells[1].

Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (31.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5022 mL 7.5110 mL 15.0220 mL
5 mM 0.3004 mL 1.5022 mL 3.0044 mL
10 mM 0.1502 mL 0.7511 mL 1.5022 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.12 mM); Clear solution

References
Molecular Weight

665.69

Formula

C₃₁H₅₄Cl₂N₄O₇

CAS No.

1226759-47-2

SMILES

O=C(CN(C)C)O[[email protected]](C1=CC=C([N+]([O-])=O)C=C1)[[email protected]@H](COC(CN(C)C)=O)NC(CCCCCCCCCCCCC)=O.[H]Cl.[H]Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
LCL521 dihydrochloride
Cat. No.:
HY-103593A
Quantity:

LCL521 dihydrochloride

Cat. No.: HY-103593A