2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. MK-447

MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins.

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MK-447

MK-447 構造式

CAS 番号 : 58456-91-0

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MK-447 関連抗体

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製品説明

MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins.

IC50 & Target[1]

PGI2

 

体外実験

MK-447 is a free radical scavenger, reduces the accumulation of the endoperoxide, PGG2 and also enhances the formation of the endoperoxide, PGH2, and other prostaglandins[1]. MK-447 (100 μM) increases the amounts of prostaglandin I2 (PGI2). MK-447 also accelerates endogenous PGI2 generation in the isolated rat aorta[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MK-447 関連抗体
体内実験

MK-447 (20 and 50 mg/kg, p.o.) blocks gastric acid secretion in the 4 hour pylorus ligated rats, but shows no effect on gastric secretion of pepsin. MK-447 (5, 10, 20 and 40 mg/kg, p.o.) dose-dependently decreases acid output in dogs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

305.16

分子式

C11H16INO
CAS 番号
SMILES

OC1=C(I)C=C(C(C)(C)C)C=C1CN
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
動物実験
[1]

Male Charles River CD rats weighing 140 and 200 g are fasted overnight with water ad lib. The rats are pretreated orally with compound (MK-447) or buffered glycol vehicle in a dosage volume of 1.0 mL/kg one hour before challenge with the necrotizing agents. The necrotizing agents [acetylsalicyclic acid at 40 suspended in 0.5% methylcellulose (1500 cps) or 37.5% ethanol] are administered p.o. in a dose volume of 0.1 mL/100 g body weight or 1 mL/rat, respectively. Rats are killed with CO2 one hour after acetylsalicylic acid or ethanol, the stomach removed, inflated with water, and opened ture. The presence of mucosal bleeding is noted and the mucosa is wiped off[1].

MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
参考文献
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MK-447 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-44758456-91-0MK447MK 447Prostaglandin ReceptorInhibitorinhibitorinhibit

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製品名:
MK-447
製品番号:
HY-100297
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