1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  2. Casein Kinase

PF-670462 

Cat. No.: HY-15490 Purity: 99.28%
Data Sheet SDS Handling Instructions

PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.

For research use only. We do not sell to patients.
PF-670462 Chemical Structure

PF-670462 Chemical Structure

CAS No. : 950912-80-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 174 In-stock
10 mg USD 158 In-stock
50 mg USD 660 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations. IC50 value: 7.7 nM Target: CK1ε PF-670462, a selective CK1 ε/δ inhibitor, causes a significant phase delay in animal models of circadian rhythm; it remains unclear whether one of the kinases has a predominant role in regulating the circadian clock. In transfected whole cell assays, it caused a concentration-related redistribution of nuclear versus cytosolic PER. When tested in free-running animals, 50 mg/kg s.c. PF-670462 produced robust phase delays when dosed at circadian time (CT)9 (-1.97 ± 0.17 h). PF-670462 attenuates methamphetamine-stimulated locomotion in vivo.

References
Molecular Weight

410.32

Formula

C₁₉H₂₂Cl₂FN₅

CAS No.

950912-80-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.28%

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Product Name:
PF-670462
Cat. No.:
HY-15490
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