1. NF-κB
  2. IKK

PS-1145 

Cat. No.: HY-18008 Purity: 99.93%
Data Sheet SDS Handling Instructions

PS-1145 is an IkappaB kinase (IKK) inhibitor with IC50 of 88 nM.

For research use only. We do not sell to patients.
PS-1145 Chemical Structure

PS-1145 Chemical Structure

CAS No. : 431898-65-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO $105 In-stock
5 mg $95 In-stock
10 mg $160 In-stock
25 mg $330 In-stock
50 mg $600 In-stock
100 mg $1050 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

PS-1145 is an IkappaB kinase (IKK) inhibitor with IC50 of 88 nM. IC50 value: 88 nM [1] Target: IKK in vitro: PS-1145 blocks TNFα-induced NF-κB activation in a dose- and time-dependent fashion in MM cells through inhibition of IκBα phosphorylation and degradation of IκBα, respectively. PS-1145 blocks the protective effect of IL-6 against Dex-induced apotosis. PS-1145 inhibits phosphorylation of IκBα in MM cells and modestly directly inhibits their growth. PS-1145 abrogates NF-κB activation related up-regulation of adhesion molecules on MM cells, MM cell to BMSC adherence, as well as the MM cell growth and survival advantage conferred both by adherence and cytokine secretion in the BM milieu.PS-1145 Inhibits IκBα Phosphorylation and NF-κB Activation in MM.1S Cells and Patient MM Cells.

References
Molecular Weight

322.75

Formula

C₁₇H₁₁ClN₄O

CAS No.

431898-65-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 43 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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PS-1145
Cat. No.:
HY-18008
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