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Cat. No.: HY-107593

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PS-1145 dihydrochloride

5 Cited Publications

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Based on 5 publication(s) in Google Scholar

PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC₅₀ value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats.

For research use only. We do not sell to patients.

CAS No.: 1049743-58-9
Formula: C₁₇H₁₃Cl₃N₄O
Molecular Weight:395.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

PS-1145 dihydrochloride Chemical Structure

CAS No.: 1049743-58-9

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Top Publications Citing

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (5)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 88 nM (IκB kinase-2)^[1]

All IKK Isoforms :

Chemical Information

CAS No. 1049743-58-9
Molecular Weight 395.67
Formula C₁₇H₁₃Cl₃N₄O
SMILES

O=C(C1=CC=CN=C1)NC2=CC(Cl)=CC3=C2NC4=C3C=CN=C4.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

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Journal Impact Factor

Sci Transl Med

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]

2018 Jul 18;10(450):eaaq1093. PMID: 30021885
Bone Joint Res

Kaempferol suppresses fibroblast-like synoviocyte proliferation in rheumatoid arthritis by targeting glutamate-cysteine ligase modifier subunit to inhibit ferroptosis resistance. [Abstract]

2026 May 8;15(5):482-496. PMID: 42097618
Exp Cell Res

Continuous NF-κB pathway inhibition promotes expansion of human phenotypical hematopoietic stem/progenitor cells through metabolism regulation. [Abstract]

2021 Feb 15;399(2):112468. PMID: 33428903
Res Sq

2025 May 15.
bioRxiv

2025 March 27.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cernackova A, et al. Cachexia induced by Yoshida ascites hepatoma in Wistar rats is not associated with inflammatory response in the spleen or brain. J Neuroimmunol. 2019;337:577068. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

PS-1145 dihydrochloride

5 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (5)
Purity & Documentation
References

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PS-1145 dihydrochloride

Publications Citing Use of MedChemExpress (MCE) PS-1145 dihydrochloride

All IKK Isoforms

Biological Activity

Chemical Information

Publications (5)

Purity & Documentation

References

Calculators

Help & FAQs

PS-1145 dihydrochloride Related Classifications

HY-107593 Related Classifications