1049743-58-9
1049743-58-9
Chemical Structure
PS-1145 dihydrochloride
- CAS No.: 1049743-58-9
- Formula:C17H13Cl3N4O
- Molecular Weight:395.67
IUPAC Name: N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide dihydrochloride
InChIKey: QTDCBADLGJZBHP-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CN=C1)NC2=CC(Cl)=CC3=C2NC4=C3C=CN=C4.[H]Cl.[H]Cl
Biological Activity: PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats[1].
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PS-1145 dihydrochloride | PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats. | |||||||||||||||||||||
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