1. Protein Tyrosine Kinase/RTK
  2. Btk

QL47 (Synonyms: BTK Inhibitor)

Cat. No.: HY-80003 Purity: 99.03%
Handling Instructions

QL47 is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 7 nM.

For research use only. We do not sell to patients.
QL47 Chemical Structure

QL47 Chemical Structure

CAS No. : 1469988-75-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 185 In-stock
5 mg USD 168 In-stock
10 mg USD 264 In-stock
50 mg USD 1056 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

QL47 is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 7 nM. IC50 Value: 7 nM Target: Btk in vitro: QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations [1]. in vivo: N/A

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.2347 mL 11.1734 mL 22.3469 mL
5 mM 0.4469 mL 2.2347 mL 4.4694 mL
10 mM 0.2235 mL 1.1173 mL 2.2347 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

447.49

Formula

C₂₇H₂₁N₅O₂

CAS No.

1469988-75-7

SMILES

O=C1N(C2=C(C=C1)C=NC3=CC=C(C4=CN(C)N=C4)C=C32)C5=CC=C(CC6)C(N6C(C=C)=O)=C5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: < 9.4 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
QL47
Cat. No.:
HY-80003
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