1469988-75-7
1469988-75-7
Chemical Structure
QL47
- CAS No.: 1469988-75-7
- Formula:C27H21N5O2
- Molecular Weight:447.49
IUPAC Name: 1-(1-acryloylindolin-6-yl)-9-(1-methyl-1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2(1H)-one
InChIKey: RTRNJQOBEOISFQ-UHFFFAOYSA-N
SMILES: O=C1N(C2=C(C=C1)C=NC3=CC=C(C4=CN(C)N=C4)C=C32)C5=CC=C(CC6)C(N6C(C=C)=O)=C5
Biological Activity: QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor of BTK with an IC50 of 7 nM[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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QL47 | 99.50% | QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor of BTK with an IC50 of 7 nM. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.89
HY-160245QL47R -
Similarity Score 0.69
HY-124645QL-X-138 -
Similarity Score 0.62
HY-115805YKL-04-085 -
Similarity Score 0.61
HY-80002BMX-IN-1 -
Similarity Score 0.60
HY-160246QL47B -
Similarity Score 0.58
HY-13002Torin 2 -
Similarity Score 0.57
HY-15281QL-IX-55 -
Similarity Score 0.56
HY-13003Torin 1 -
Similarity Score 0.55
HY-151808JS25 -
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References
- [1]. Liang Y, et al. Structure-Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent. ACS Med Chem Lett. 2017;8(3):344-349. Published 2017 Feb 3. [Content Brief]
- [2]. de Wispelaere M, et al. A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation. J Biol Chem. 2020;295(6):1694-1703. [Content Brief]
- [3]. Wu H, et al. Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma. ACS Chem Biol. 2014;9(5):1086-1091. [Content Brief]
