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  4. QL47R

QL47R is an approximately isosteric analogue of QL47 (HY-80003). QL47R dose not inhibit the biochemical kinase activity of BTK at concentrations below 10 μM. QL47R dose not display antiproliferative activity on B-Cell Lymphoma Cell Lines at concentrations of less than 10 μM.

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QL47R Chemical Structure

QL47R Chemical Structure

CAS No. : 1579278-89-9

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1 mg USD 495 In-stock
5 mg USD 1235 In-stock
10 mg USD 1975 In-stock
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100 mg   Get quote  

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QL47R Related Antibodies

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Description

QL47R is an approximately isosteric analogue of QL47 (HY-80003). QL47R dose not inhibit the biochemical kinase activity of BTK at concentrations below 10 μM. QL47R dose not display antiproliferative activity on B-Cell Lymphoma Cell Lines at concentrations of less than 10 μM[1].

Molecular Weight

449.50

Formula

C27H23N5O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C=CC2=CN=C3C=CC(C4=CN(C)N=C4)=CC3=C2N1C5=CC=C6C(N(CC6)C(CC)=O)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (222.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2247 mL 11.1235 mL 22.2469 mL
5 mM 0.4449 mL 2.2247 mL 4.4494 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2247 mL 11.1235 mL 22.2469 mL 55.6174 mL
5 mM 0.4449 mL 2.2247 mL 4.4494 mL 11.1235 mL
10 mM 0.2225 mL 1.1123 mL 2.2247 mL 5.5617 mL
15 mM 0.1483 mL 0.7416 mL 1.4831 mL 3.7078 mL
20 mM 0.1112 mL 0.5562 mL 1.1123 mL 2.7809 mL
25 mM 0.0890 mL 0.4449 mL 0.8899 mL 2.2247 mL
30 mM 0.0742 mL 0.3708 mL 0.7416 mL 1.8539 mL
40 mM 0.0556 mL 0.2781 mL 0.5562 mL 1.3904 mL
50 mM 0.0445 mL 0.2225 mL 0.4449 mL 1.1123 mL
60 mM 0.0371 mL 0.1854 mL 0.3708 mL 0.9270 mL
80 mM 0.0278 mL 0.1390 mL 0.2781 mL 0.6952 mL
100 mM 0.0222 mL 0.1112 mL 0.2225 mL 0.5562 mL
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QL47R Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QL47R1579278-89-9OthersInhibitorinhibitorinhibit

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