2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-114793
    AL-12180 748816-43-5 98%
    AL-12180 is a potent and selective FP-receptor agonist with a Ki of 143 nM. AL-12180 stimulates the mobilization of intracellular Ca2+ in h-TM and h-CM cells with EC50s of 111 and 11 nM, respectively.
    AL-12180
  • HY-114850
    5-trans Prostaglandin F2β 36150-02-4 98%
    5-trans Prostaglandin F2β (5-trans-PGF2β) is the 9β-hydroxy isomer of 5-trans PGF2α.
    5-trans Prostaglandin F2β
  • HY-114867
    (15R)-Bimatoprost 1163135-92-9 98%
    (15R)-Bimatoprost (15(R)-17-phenyl trinor PGF2α ethyl amide) is a prostaglandin analog used to study glaucoma and ocular hypertension. (15R)-Bimatoprost is an isomer of Bimatoprost with an inverted (β) hydroxyl group on C-15.
    (15R)-Bimatoprost
  • HY-114892
    15-A2t-Isoprostane 474391-66-7 98%
    15-A2t-Isoprostane (8-iso Prostaglandin A2) is an isoprostaglandin produced by the non-enzymatic oxidation of arachidonic acid.
    15-A2t-Isoprostane
  • HY-114921
    α-(2-Carboxycyclopropyl)glycine 22255-17-0 98%
    α-(2-Carboxycyclopropyl)glycine is a male sterilant. α-(2-Carboxycyclopropyl)glycine does not affect IAA (HY-18569B)-induced ethylene formation, does not induce ethylene biosynthesis, and resists conversion to ethylene in vitro or in wheat coleoptile segments.
    α-(2-Carboxycyclopropyl)glycine
  • HY-114948
    Rimiterol 32953-89-2 98%
    Rimiterol is a selective β2-adrenergic receptor agonist. Rimiterol activates adenylate cyclase and elevates intracellular cAMP levels to cause smooth muscle relaxation. Rimiterol is promising for research of asthma.
    Rimiterol
  • HY-115615
    VUF11207 TFA 1492153-74-8 98%
    VUF11207 (Compound 29) TFA is a CXCR7 agonist (pKi of 8.1) that induces recruitment of β-arrestin2 (pEC50 of 8.8) and subsequent internalization (pEC50 of 7.9) of CXCR7.
    VUF11207 TFA
  • HY-115769
    1,2-Didecanoylglycerol 17863-69-3 98%
    1,2-Didecanoylglycerol, a synthetic diacylglycerol, is metabolized by platelets to 1,2-didecanoylphosphatidic acid (PA10) and activates protein kinase C (PKC).
    1,2-Didecanoylglycerol
  • HY-116066
    YM471 free base 183173-00-4 98%
    YM471 free base is a non-peptide antagonist of vasopressin V1A and V2 receptors with potent and persistent antagonistic activity. YM471 exhibits high affinity for rat V1A and V2 receptors with K values of 0.16 and 0.77 nM, respectively.
    YM471 free base
  • HY-116169
    KUC-7322 255734-04-4 98%
    KUC-7322, a selective β3 -adrenoceptor agonist, is the active form of ritobegron. Ritobegron decreases intravesical pressure with minimal effects on the cardiovascular system.
    KUC-7322
  • HY-116219
    WB2838 16386-65-5 98%
    WB2838 is a non-steroidal androgen-receptor antagonist (IC50: 0.8 μM for partially purified rat prostate cytosol receptor). WB2838 exhibits anti-cancer activity against androgen-responsive breast cancer. WB2838 also shows the inhibitory activity against the growth of the ventral prostate induced by Testosterone propionate.
    WB2838
  • HY-116222
    A 53693 115103-48-5 98%
    A 53693 is a rigid catecholamine with selective adrenergic agonist activity. A 53693 has affinity for certain rat alpha-2 receptor subtypes. A 53693 shows high selectivity for alpha-2 receptors and, in contrast, has low affinity for alpha-1 receptors. A 53693 is used as a probe in biological studies to explore the molecular interactions of alpha agonist compounds.
    A 53693
  • HY-116250
    Prostaglandin D2-1-glyceryl ester 309260-52-4 98%
    Prostaglandin D2-1-glyceryl ester (PGD2-G; PGD2 2-glyceryl ester).
    Prostaglandin D2-1-glyceryl ester
  • HY-116591
    8-Iso-15-keto prostaglandin F2β 1621482-36-7 98%
    8-ISo-15-keto prostaglandin F2β is a potential metabolite of 8-Iso PGF2β via the 15-hydroxy-PG dehydrogenase pathway. 8-iso PGF2β constricts pulmonary veins in dogs and pigs.
    8-Iso-15-keto prostaglandin F2β
  • HY-116613
    FR-181877 172936-99-1 98%
    FR-181877 (compound 4) is a non-prostaglandin PGI2 agonist. FR-181877 inhibits ADP (HY-W010918)-induced human platelet aggregation with an IC50 value of 0.081 μM.
    FR-181877
  • HY-116638
    AHR-5333 60284-71-1 98%
    AHR-5333 is a selective human blood neutrophil 5-lipoxygenase inhibitor. AHR-5333 exhibits potent, long-acting activity in rat and guinea pig in vivo models of immediate hypersensitivity.
    AHR-5333
  • HY-116640
    Amorphigenin 4208-09-7 98%
    Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders.
    Amorphigenin
  • HY-116806
    AF-2785 252025-48-2 98%
    AF-2785 is a potent CFTR blocker. AF-2785 inhibits the cAMP-activated chloride current in rat epididymal cells with an IC50 of 170.6 μM. AF-2785 can be used in research related to contraceptives.
    AF-2785
  • HY-116843
    (15S)-15-Methylprostaglandin E2 35700-27-7 98%
    (15S)-15-Methylprostaglandin E2 ((15R)-15-Methyl-PGE) is a prostaglandin E2 analog with the potential to prevent gastrointestinal bleeding and protect gastrointestinal cells.
    (15S)-15-Methylprostaglandin E2
  • HY-117038
    Anordiol 1045-29-0 98%
    Anordiol is an antiestrogenic compound with weak estrogenic activity. It can reduce the parameters of uterine growth (including uterine wet weight, soluble protein content, and DNA content) induced by estradiol in rats and can also regulate the estrous cycle in rats. Anordiol holds potential application value in the research of antiestrogen-related diseases.
    Anordiol
Cat. No. Product Name / Synonyms Application Reactivity