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Cat. No.: HY-116613

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FR-181877

FR-181877 (compound 4) is a non-prostaglandin PGI₂ agonist. FR-181877 inhibits ADP (HY-W010918)-induced human platelet aggregation with an IC₅₀ value of 0.081 μM.

For research use only. We do not sell to patients.

CAS No.: 172936-99-1
Formula: C₃₀H₂₈N₂O₄
Molecular Weight:480.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

FR-181877 Chemical Structure

CAS No.: 172936-99-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

FR-181877 (compound 4) is a non-prostaglandin PGI₂ agonist. FR-181877 inhibits ADP (HY-W010918)-induced human platelet aggregation with an IC₅₀ value of 0.081 μM^[1].

All Prostaglandin Receptor Isoforms :

Chemical Information

CAS No. 172936-99-1
Molecular Weight 480.55
Formula C₃₀H₂₈N₂O₄
SMILES

OC(COC1=C(CC2)C(C[C@H]2CN(C(C=C3)=O)N=C3C(C4=CC=CC=C4)C5=CC=CC=C5)=CC=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tsubaki K, et al. A novel pyridazinone derivative as a nonprostanoid PGI2 agonist[J]. Bioorganic & medicinal chemistry letters, 2000, 10(24): 2787-2790. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
Purity & Documentation
References

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FR-181877

All Prostaglandin Receptor Isoforms