A novel pyridazinone derivative as a nonprostanoid PGI2 agonist

  • Bioorg Med Chem Lett. 2000 Dec 18;10(24):2787-90. doi: 10.1016/s0960-894x(00)00571-0.
K Tsubaki  1 ,  K Taniguchi ,  S Tabuchi ,  O Okitsu ,  K Hattori ,  J Seki ,  K Sakane ,  H Tanaka
Affiliations
  • 1. Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd, Osaka, Japan.
PMID: 11133092 DOI: 10.1016/s0960-894x(00)00571-0
Abstract

A novel optically pure pyridazinone derivative was synthesized and identified as a nonprostanoid PGI2 agonist. It inhibited ADP-induced aggregation of human platelets with an IC50 value of 0.081 microM and has high oral bioavailability (56%) with a long half-life (4.3 h) in rats.

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