2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N1377R
    Nevadensin (Standard) 10176-66-6 98%
    Nevadensin (Standard) (Lysionotin (Standard)) is the analytical standard of Nevadensin (HY-N1377). This product is intended for research and analytical applications. Nevadensin, a natural flavonoid, is a selective human carboxylesterase 1 (hCE1) inhibitor with an IC50 of 2.64 μM. Nevadensin is more selective for hCE1 than hCE2 (IC50 of 132.8 μM). Nevadensin can induce apoptosis and DNA damage in cancer cells. Nevadensin has a variety of pharmacological effects such as anti-inflammatory, anti-tumour, anti-hypertensive, anti-tubercular, antitussive, antioxidant and anti-microbial activities.
    Nevadensin (Standard)
  • HY-N15483
    13,14-Dihydro-15-keto prostaglandin J2 2230717-14-1
    13,14-Dihydro-15-keto prostaglandin J2 (13,14-Dihydro-15-keto-PGJ2) is the dehydration product of 13,14-dihydro-15-keto PGD2 (HY-118830).
    13,14-Dihydro-15-keto prostaglandin J2
  • HY-N15524
    Thalictoside 74213-96-0 98%
    Thalictoside is found in A. squamosa L. Thalictoside is a sEH inhibitor (IC50: 20.2 µM). Thalictoside exerts anti-osteoporotic effects through an estrogen-like mechanism. Thalictoside can be used in the research of cardiovascular and urinary diseases.
    Thalictoside
  • HY-N15590
    Solstitialin A 22738-70-1
    Solstitialin A is a guaianolide-type sesquiterpene lactone. Solstitialin A can be isolated from Centaurea solstitialis L. ssp. Solstitialis. A mixture of solstitialin A and 13-acetyl solstitialin A has an inhibitory effect on ethanol- and Indomethacin (HY-14397)-induced ulcers. Solstitialin A can be used in research related to peptic ulcers.
    Solstitialin A
  • HY-N15700
    Toralactone 9-O-triglucoside 1002727-59-4 98%
    Toralactone 9-O-triglucoside (Compound 2) is a phenolic trisaccharide. Toralactone 9-O-triglucoside can be isolated from Cassia seed. Toralactone 9-O-triglucoside can be used in the research of estrogen-related diseases such as breast cancer, prostate cancer, osteoporosis and cardiovascular disease.
    Toralactone 9-O-triglucoside
  • HY-N15754
    3-Hydroxy-2-methylglutaric acid 54665-33-7
    3-Hydroxy-2-methylglutaric acid is a carboxylic acid metabolite. 3-Hydroxy-2-methylglutaric acid can be isolated from the flower Veronica incana L. 3-Hydroxy-2-methylglutaric acid can be used for upper respiratory tract diseases, malignant neoplasms, gastrointestinal tract and genitourinary system disorders and diabetes mellitus research.
    3-Hydroxy-2-methylglutaric acid
  • HY-N16670
    Sorocein H 157382-82-6 98%
    Sorocein H (Sanggenon P) is a mulberry Diels–Alder‑type adduct (MDAA). Sorocein H has inhibitory activity against tyrosinase with an IC50 of 6.49 μM. Sorocein H can reduce melanin synthesis. Sorocein H can be used in the research of pigment-related diseases.
    Sorocein H
  • HY-N16764
    (rel)-Salcolin A 1977557-69-9 98%
    (rel)-Salcolin A is a flavonoid lignan compound with anticancer, anti-inflammatory, and neuroprotective activities. (rel)-Salcolin A has IC50 values ??of 66.69 μM and 56.12 μM against anaplastic thyroid carcinoma cells (HTH83) and papillary thyroid carcinoma cells (TPC1), respectively. (rel)-Salcolin A also inhibits LPS-induced NO production with an IC50 of 14.65 μM. (rel)-Salcolin A exerts its effects by inducing necroptosis in thyroid cancer cells, inhibiting the production of the inflammatory factor NO, and protecting against glutamate-induced neuronal cell damage, with a neuroprotective E50 of 47.44 μM. (rel)-Salcolin A can be used in research related to thyroid cancer, anti-inflammation, and neuroprotection. (rel)-Salcolin A can be naturally extracted from the leaves of Casearia arborea and the stems of Zea mays (corn).
    (rel)-Salcolin A
  • HY-N16905
    Diosbulbin I 1187951-05-8
    Diosbulbin I is a furan-type nor-diterpenoid compound that can be naturally extracted from the tubers of Dioscorea bulbifera L. Dioscorea bulbifera L. is traditionally used to research thyroid diseases and tumors.
    Diosbulbin I
  • HY-N17361
    Methylgerambullone 160954-12-1
    Methylgerambullone is a constitutional isomer of Methylisogerambullone. Methylgerambullone can be isolated from the methanolic leaf extract of Glycosmis angustifolia. Methylgerambullone shows the relaxatory effect on guinea-pig isolated ileum precontracted with Acetylcholine.
    Methylgerambullone
  • HY-N18101
    Corymbolone 97094-19-4
    Corymbolone is an eudesmane-type sesquiterpene ketol found in the rhizomes of Cyperus corymbosus. Corymbolone can be used in research on gynecological diseases.
    Corymbolone
  • HY-N18387
    trans-Psoralenoside
    trans-Psoralenoside is the trans isomer of Psoralenoside (HY-N7503). trans-Psoralenoside is present in the aerial parts of Ficus palmata. trans-Psoralenoside can be used in studies of liver diseases, kidney diseases and peptic ulcers.
    trans-Psoralenoside
  • HY-N1919A
    Ajmalicine hydrochloride 4373-34-6 98%
    Ajmalicine (Raubasine) hydrochloride is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine hydrochloride is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine hydrochloride also can be used as anti-hypertensive, and serpentine, with sedative activity.
    Ajmalicine hydrochloride
  • HY-N19715
    Asperosaponin H1 159993-47-2 98%
    Asperosaponin H1 is a triterpenoid saponin (octasaccharide saponin) found in the roots of Dipsacus asperoides C.Y. Cheng et T.M. Ai. Asperosaponin H1 can be used for research on liver and kidney diseases.
    Asperosaponin H1
  • HY-N2534R
    Karanjin (Standard) 521-88-0
    Karanjin (Standard) is the analytical standard of Karanjin. This product is intended for research and analytical applications. Karanjin is an orally active furanoflavonoid which can be isolated from several Leguminosae. Karanjin exhibits evident anti-diabetic, anti-cancer, anti-inflammatory, antioxidant, anticolitis, anti-ulcer, anti-Alzheimer properties and multiple insect repellent/insecticidal, acaricide properties, suggesting the potential of Karanjin to be applied to relevant research.
    Karanjin (Standard)
  • HY-N6257R
    Cafestol (Standard) 469-83-0
    Cafestol (Standard) is the analytical standard of Cafestol. This product is intended for research and analytical applications. Cafestol is an orally active diterpenoid and an inhibitor of ERK2. Cafestol has elevated blood lipids, anti-inflammatory, anti-angiogenic and anti-diabetic activities. In addition, Cafestol induces tumor cell apoptosis and autophagy, which can be used in the study of cancer.
    Cafestol (Standard)
  • HY-N6678S
    (Rac)-Zearalanone-d6 1795020-90-4 98%
    (Rac)-Zearalanone-d6 is the racemate of Zearalanone. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system.
    (Rac)-Zearalanone-d6
  • HY-N6741R
    β-Zearalenol (Standard) 71030-11-0
    β-Zearalenol (Standard) is the analytical standard of β-Zearalenol. This product is intended for research and analytical applications. β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level.
    β-Zearalenol (Standard)
  • HY-N6896R
    Isoviolanthin (Standard) 40788-84-9
    Isoviolanthin (Standard) is the analytical standard of Isoviolanthin (HY-N6896). This product is intended for research and analytical applications. Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2 and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma.
    Isoviolanthin (Standard)
  • HY-N7748A
    Epi-cryptoacetalide 132152-57-9 98%
    Epi-cryptoacetalide is a natural diterpenoid. Epi-cryptoacetalide reveals high affinity to ER-α and PGE2 receptor (EP2 subtype) with Ki values of 0.3 μM and 1.92 μM, respectively. Epi-cryptoacetalide has anti-endometriosis activities.
    Epi-cryptoacetalide
Cat. No. Product Name / Synonyms Application Reactivity