2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-19274
    ZD-1611 186497-38-1 98%
    ZD-1611 is a potent, orally active, selective ETA receptor antagonist, used for the research of ischemic stroke.
    ZD-1611
  • HY-19284
    FR-146687 146939-64-2 98%
    FR-146687 (FK 687) is a selective and orally active 5α-reductase inhibitor with IC50s of 1.7 nM and 4.6 nM for rat and human 5α-reductases, respectively. FR-146687 shows no inhibitory effects on other steroid oxidoreductases.
    FR-146687
  • HY-19670
    Befetupitant 290296-68-3 98%
    Befetupitant is a high-affinity, nonpeptide, competitive tachykinin 1 receptor (NK1R) antagonist.
    Befetupitant
  • HY-19673
    KUL-7211 220129-58-8 98%
    KUL 7211 is a selective β-adrenoceptor agonist.
    KUL-7211
  • HY-19690
    Ritobegron hydrochloride 476333-91-2 98%
    Ritobegron, a prodrug of the active compound, KUC-7322, is a selective β3 -adrenoceptor agonist. Ritobegron decreases intravesical pressure with minimal effects on the cardiovascular system.
    Ritobegron hydrochloride
  • HY-19880
    RWJ-676070 813426-25-4 98%
    RWJ-676070 is a dual vasopressin V(1A)/V(2) receptor antagonist with an Ki value of 1.4 nM and 14 nM respectly.
    RWJ-676070
  • HY-19890
    Aminaftone 14748-94-8 98%
    Aminaftone, a derivative of 4-aminobenzoic acid, downregulates endothelin-1 (ET-1) production in vitro by interfering with the transcription of the pre-pro-ET-1 gene.
    Aminaftone
  • HY-50761
    Libenzapril 109214-55-3 98%
    Libenzapril (Abutapril; CGS-16617) is an orally active, potent direct-acting angiotensin-converting-enzyme (ACE) inhibitor. Libenzapril has the potential for ischemia-induced heart failure research.
    Libenzapril
  • HY-B0163
    Detomidine 76631-46-4 98%
    Detomidine, an imidazole derivative, is a potent α2-adrenergic agonist. Detomidine produces dose-dependent analgesic effects.
    Detomidine
  • HY-B0528
    Octopamine 104-14-3 99.52%
    Octopamine is a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure.
    Octopamine
  • HY-B0922
    Dicloralurea 116-52-9 98.0%
    Dicloralurea is a veterinary food additive that inhibits methane production in herbicide ruminants, acts as a growth stimulant.
    Dicloralurea
  • HY-B1694
    Methoxyphenamine 93-30-1 98%
    Methoxyphenamine is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.
    Methoxyphenamine
  • HY-B1970
    o,p'-DDT 789-02-6 98%
    o,p'-DDT (2,4'-DDT) is a chlorinated organic pesticide with estrogenic activity. o,p'-DDT is persistent in the environment, can accumulate in organisms and disrupt the endocrine system. o,p'-DDT is used in agriculture as a pesticide, especially for controlling insect pests. The use of o,p'-DDT has led to toxic effects in organisms, raising widespread concern about its environmental and health effects. o,p'-DDT has also led to research into its long-term effects in ecosystems.
    o,p'-DDT
  • HY-B2044
    Bromopropylate 18181-80-1 98%
    Bromopropylate is a pesticide with moderate anti-androgenic activities.
    Bromopropylate
  • HY-G0011
    Netupitant metabolite Netupitant N-oxide 910808-11-6 98%
    Netupitant N-oxide is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.
    Netupitant metabolite Netupitant N-oxide
  • HY-G0012
    Netupitant metabolite Monohydroxy Netupitant 910808-12-7 98%
    Monohydroxy Netupitant is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.
    Netupitant metabolite Monohydroxy Netupitant
  • HY-N4054
    Henryoside 72021-23-9 98%
    Henryoside, an acylated salicin bis-glucoside from Viburnum veitchii, exhibits spasmolytic and uterotonic properties.
    Henryoside
  • HY-N8366
    Alloisoimperatorin 35214-83-6 98%
    Alloisoimperatorin (Compound 5) is a phytoestrogen that can be isolated from Angelica dahurica. Alloisoimperatorin can induce alkaline phosphatase (AP) activity with an EC50 of 0.8 μg/mL. Alloisoimperatorin can be used in the study of hormone-dependent cancers and the alleviation of menopausal symptoms.
    Alloisoimperatorin
  • HY-N8550
    Cortolone 516-42-7 98%
    Cortolone (α-Cortolone) is a metabolite of the glucocorticoid cortisol (Hydrocortisone (HY-N0583)). Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
    Cortolone
  • HY-N9520
    1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone 120693-52-9 98%
    Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC50=48.2 μM). Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is a quinolone alkaloid from Evodia rutaecarpa.
    1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone
Cat. No. Product Name / Synonyms Application Reactivity