1. Neuronal Signaling GPCR/G Protein Metabolic Enzyme/Protease
  2. Adrenergic Receptor Endogenous Metabolite
  3. Octopamine

Octopamine is a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure.

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Octopamine

Octopamine Chemical Structure

CAS No. : 104-14-3

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Description

Octopamine is a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
24 nM
Compound: octopamine
Activity at SER3 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assay
Activity at SER3 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assay
[PMID: 18033297]
Molecular Weight

153.18

Formula

C8H11NO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC=C(O)C=C1)CN

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Octopamine
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HY-B0528
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