1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Adrenergic Receptor
    Endogenous Metabolite
  3. Octopamine hydrochloride

Octopamine hydrochloride (Synonyms: (±)-p-Octopamine hydrochlorid)

Cat. No.: HY-B0528A Purity: 99.28%
Handling Instructions

Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure.

For research use only. We do not sell to patients.

Octopamine hydrochloride Chemical Structure

Octopamine hydrochloride Chemical Structure

CAS No. : 770-05-8

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Description

Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure[1][2][3].

IC50 & Target[1][2]

Human Endogenous Metabolite

 

α2-adrenergic receptor

 

In Vitro

Octopamine has a prominent role in influencing multiple physiological events: (a) as a neuromodulator, it regulates desensitization of sensory inputs, arousal, initiation, and maintenance of various rhythmic behaviors and complex behaviors such as learning and memory; (b) as a neurotransmitter, it regulates endocrine gland activity; and (c) as a neurohormone, it induces mobilization of lipids and carbohydrates. Octopamine exerts its effects by binding to specific proteins that belong to the superfamily of G protein-coupled receptors and share the structural motif of seven transmembrane domains[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

189.64

Formula

C₈H₁₂ClNO₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (527.31 mM)

H2O : ≥ 50 mg/mL (263.66 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2731 mL 26.3657 mL 52.7315 mL
5 mM 1.0546 mL 5.2731 mL 10.5463 mL
10 mM 0.5273 mL 2.6366 mL 5.2731 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (527.31 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Octopamine hydrochloride
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HY-B0528A
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