Octopamine-d4 hydrochloride
Based on 1 Customer Validation
Octopamine-d4 (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1219803-62-9
- Formula: C8H9D3ClNO2
- Molecular Weight:192.66
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1219803-62-9
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Unlabeled Cas 770-05-9
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Appearance Solid
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Molecular Weight 192.66
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Formula C8H9D3ClNO2
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Color Light brown to brown
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SMILES
NC([2H])([2H])C(C1=CC=C(C=C1)O)([2H])O.[H]Cl
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Synonyms
(±)-p-Octopamine-d4 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (519.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 50 mg/mL (259.52 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Farooqui T. Octopamine-mediated neuromodulation of insect senses. Neurochem Res. 2007;32(9):1511-1529. [Content Brief]
[3]. Roeder T. Octopamine in invertebrates. Prog Neurobiol. 1999;59(5):533-561. [Content Brief]
[4]. Axelrod J, et al. Octopamine. Nature. 1977;265(5594):501-504. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 5.1905 mL | 25.9525 mL | 51.9049 mL | 129.7623 mL |
| 5 mM | 1.0381 mL | 5.1905 mL | 10.3810 mL | 25.9525 mL | |
| 10 mM | 0.5190 mL | 2.5952 mL | 5.1905 mL | 12.9762 mL | |
| 15 mM | 0.3460 mL | 1.7302 mL | 3.4603 mL | 8.6508 mL | |
| 20 mM | 0.2595 mL | 1.2976 mL | 2.5952 mL | 6.4881 mL | |
| 25 mM | 0.2076 mL | 1.0381 mL | 2.0762 mL | 5.1905 mL | |
| 30 mM | 0.1730 mL | 0.8651 mL | 1.7302 mL | 4.3254 mL | |
| 40 mM | 0.1298 mL | 0.6488 mL | 1.2976 mL | 3.2441 mL | |
| 50 mM | 0.1038 mL | 0.5190 mL | 1.0381 mL | 2.5952 mL | |
| 60 mM | 0.0865 mL | 0.4325 mL | 0.8651 mL | 2.1627 mL | |
| 80 mM | 0.0649 mL | 0.3244 mL | 0.6488 mL | 1.6220 mL | |
| 100 mM | 0.0519 mL | 0.2595 mL | 0.5190 mL | 1.2976 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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