770-05-8
Chemical Structure
Octopamine hydrochloride
Synonym(s): (±)-p-Octopamine hydrochloride
- CAS No.: 770-05-8
- Formula:C8H12ClNO2
- Molecular Weight:189.64
IUPAC Name: 4-(2-amino-1-hydroxyethyl)phenol hydrochloride
InChIKey: PUMZXCBVHLCWQG-UHFFFAOYSA-N
SMILES: OC(C1=CC=C(O)C=C1)CN.Cl
Biological Activity: Octopamine hydrochloride ((±)-p-Octopamine hydrochloride) is an orally active neurotransmitter and neuromodulator that can cross the blood-brain barrier. Octopamine hydrochloride activates Octopamine hydrochloride receptors (Octopamine hydrochloride receptor), G protein-coupled/Gαs-coupled receptors (G protein-coupled/Gαs-coupled receptor), adenylyl cyclase (adenylyl cyclase)/cAMP, calcium, and hyperpolarizing conductance increases. Octopamine hydrochloride can be used in research on various neurological diseases, metabolic diseases, and cardiovascular and cerebrovascular diseases[1][2][3][4].
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Octopamine hydrochloride | 99.61% | Octopamine hydrochloride ((±)-p-Octopamine hydrochloride) is an orally active neurotransmitter and neuromodulator that can cross the blood-brain barrier. Octopamine hydrochloride activates Octopamine hydrochloride receptors (Octopamine hydrochloride receptor), G protein-coupled/Gαs-coupled receptors (G protein-coupled/Gαs-coupled receptor), adenylyl cyclase (adenylyl cyclase)/cAMP, calcium, and hyperpolarizing conductance increases. Octopamine hydrochloride can be used in research on various neurological diseases, metabolic diseases, and cardiovascular and cerebrovascular diseases. | ||||||||||||||||||||
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Octopamine hydrochloride (Standard) | 99.90% | Octopamine (hydrochloride) (Standard) is the analytical standard of Octopamine (hydrochloride). This product is intended for research and analytical applications. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure. | ||||||||||||||||||||
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References
- [1]. Axelrod J, et al. Octopamine. Nature. 1977 Feb 10;265(5594):501-4. [Content Brief]
- [2]. Kaya-Zeeb S, et al. Octopamine drives honeybee thermogenesis. eLife. 2022 Mar 15;11:e74334.
- [3]. Farooqui T, et al. Octopamine-mediated neuromodulation of insect senses. Neurochemical research. 2007 Sep;32(9):1511-29. [Content Brief]
- [4]. Selcho M, et al. Linking physiological processes and feeding behaviors by octopamine. Current opinion in insect science. 2019 Dec;36:125-130.
