FR-146687
FR-146687 (FK 687) is a selective and orally active 5α-reductase inhibitor with IC50s of 1.7 nM and 4.6 nM for rat and human 5α-reductases, respectively. FR-146687 shows no inhibitory effects on other steroid oxidoreductases.
For research use only. We do not sell to patients.
- CAS No.: 146939-64-2
- Formula: C33H37NO4
- Molecular Weight:511.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.7 nM (Rat 5α-reductase) and 4.6 nM (Human 5α-reductase)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4-week-old immature castrated male rats injected with Testosterone propionate (TP)[1]
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Dosage:0.032 mg/kg, 0.32 mg/kg, 3.2 mg/kg
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Administration:po; 2, 7, 14, or 21 days
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Result:Dose-dependently reduced ventral prostate and seminal vesicle weight at doses above 0.1 mg/kg.
Chemical Information
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CAS No. 146939-64-2
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Molecular Weight 511.65
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Formula C33H37NO4
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SMILES
O=C(O)CCCC1=CC(C(C2=CC=C(O[C@H](C3=CC=C(CC(C)C)C=C3)CCC)C=C2)=O)=C4C=CC=CN14
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Synonyms
FK 687; TF 505
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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