146939-64-2
146939-64-2
Chemical Structure
FR-146687
Synonym(s): FK 687; TF 505
- CAS No.: 146939-64-2
- Formula:C33H37NO4
- Molecular Weight:511.65
IUPAC Name: (S)-4-(1-(4-(1-(4-isobutylphenyl)butoxy)benzoyl)indolizin-3-yl)butanoic acid
InChIKey: MVPWJFWMEIXDQW-HKBQPEDESA-N
SMILES: O=C(O)CCCC1=CC(C(C2=CC=C(O[C@H](C3=CC=C(CC(C)C)C=C3)CCC)C=C2)=O)=C4C=CC=CN14
Biological Activity: FR-146687 (FK 687) is a selective and orally active 5α-reductase inhibitor with IC50s of 1.7 nM and 4.6 nM for rat and human 5α-reductases, respectively. FR-146687 shows no inhibitory effects on other steroid oxidoreductases[1].
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FR-146687 | FR-146687 (FK 687) is a selective and orally active 5α-reductase inhibitor with IC50s of 1.7 nM and 4.6 nM for rat and human 5α-reductases, respectively. FR-146687 shows no inhibitory effects on other steroid oxidoreductases. | |||||||||||||||||||||
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References
Keywords
