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Cat. No.: HY-19880

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RWJ-676070

RWJ-676070 is a dual vasopressin V(1A)/V(2) receptor antagonist with an K_i value of 1.4 nM and 14 nM respectly.

For research use only. We do not sell to patients.

CAS No.: 813426-25-4
Formula: C₃₀H₂₆ClFN₂O₅
Molecular Weight:548.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

RWJ-676070 Chemical Structure

CAS No.: 813426-25-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

RWJ-676070 is a dual vasopressin V(1A)/V(2) receptor antagonist with an K_i value of 1.4 nM and 14 nM respectly^[1].

All Vasopressin Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	30 nM Compound: 3	Antagonist activity at rat vasopressin V2 receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced cAMP levels Antagonist activity at rat vasopressin V2 receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced cAMP levels	[PMID: 17942308]
HEK293	IC₅₀	34 nM Compound: 3	Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cells Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cells	[PMID: 17942308]
HEK293	IC₅₀	38 nM Compound: 3	Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level	[PMID: 17942308]
HEK293	IC₅₀	5 nM Compound: 3	Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells	[PMID: 17942308]
HEK293	IC₅₀	52 nM Compound: 3	Antagonist activity at human vasopressin V2 receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced cAMP levels Antagonist activity at human vasopressin V2 receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced cAMP levels	[PMID: 17942308]
HEK293	IC₅₀	640 nM Compound: 3	Antagonist activity at rat vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level Antagonist activity at rat vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level	[PMID: 17942308]

Chemical Information

CAS No. 813426-25-4
Molecular Weight 548.99
Formula C₃₀H₂₆ClFN₂O₅
SMILES

O=C(C(CC1)=C[C@@]21CCN(C(C3=CC=C(NC(C4=CC(F)=CC=C4Cl)=O)C(OC)=C3)=O)C5=CC=CC=C5C2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Joseph W Gunnet, et al. Pharmacological characterization of RWJ-676070, a dual vasopressin V(1A)/V(2) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590(1-3):333-42. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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RWJ-676070

All Vasopressin Receptor Isoforms