2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-105184R
    YM511 (Standard) 148869-05-0
    YM511 (Standard) is the analytical standard of YM511 (HY-105184). This product is intended for research and analytical applications. YM511 is a highly specific non-steroidal aromatase inhibitor. YM511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM511 slightly inhibits production of other steroid hormones. YM511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones.
    YM511 (Standard)
  • HY-105318R
    LGD-2226 (Standard) 328947-93-9
    LGD-2226 (Standard) is the analytical standard of LGD-2226 (HY-105318). This product is intended for research and analytical applications. LGD-2226 is a selective and orally active androgen receptor modulator with an EC50 of 0.2 nM and a Ki of 1.5 nM for human androgen receptor. LGD-2226 shows tissue selectivity in animal models, with reduced effects on prostate compared to muscle. LGD-2226 can be used for muscle wasting, osteoporosis and sexual dysfunction.
    LGD-2226 (Standard)
  • HY-106907R
    Furprofen (Standard) 66318-17-0 98%
    Furprofen (Standard) is the analytical standard of Furprofen (HY-106907). This product is intended for research and analytical applications. Furprofen is an non-steroidal anti-inflammatory drug (NSAID) with analgesic properties. Furprofen acts via the inhibition of prostaglandin (PGE) synthesis. Furprofen can be treated orally for the relief of pain.
    Furprofen (Standard)
  • HY-106910R
    Saredutant (Standard) 142001-63-6
    Saredutant (Standard) is the analytical standard of Saredutant. This product is intended for research and analytical applications. Saredutant is a selective NK2 receptor antagonist.
    Saredutant (Standard)
  • HY-106993R
    Cipralisant (Standard) 213027-19-1 98%
    Cipralisant (Standard) (GT-2331 (Standard)) is the analytical standard of Cipralisant (HY-106993). This product is intended for research and analytical applications. Cipralisant (GT-2331) is an orally active, low-toxicity, potent, selective, high affinity histamine H3 receptor full antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor. Cipralisant has the potential for attention-deficit hyperactivity disorder research. Cipralisant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Cipralisant (Standard)
  • HY-107002A
    Lergotrile mesylate 51473-23-5 98%
    Lergotrile mesylate is a potent and orally active dopamine agonist and a prolactin secretion inhibitor. Lergotrile mesylate inhibits prolactin release from pituitaries by activating an adenohypophyseal dopamine receptor. Lergotrile mesylate has the potential for the research of Parkinson's disease.
    Lergotrile mesylate
  • HY-107051R
    GW 766994 (Standard) 408303-43-5 98%
    GW 766994 (Standard) (GW 994 (Standard)) is the analytical standard of GW 766994 (HY-107051). This product is intended for research and analytical applications. GW 766994 (GW 994) is an orally active and specific chemoKine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research.
    GW 766994 (Standard)
  • HY-107139R
    JNJ-10229570 (Standard) 524923-88-4 98%
    JNJ-10229570 (Standard) is the analytical standard of JNJ-10229570 (HY-107139). This product is intended for research and analytical applications. JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.
    JNJ-10229570 (Standard)
  • HY-107381R
    (+)-Cloprostenol (Standard) 54276-21-0
    (+)-Cloprostenol (Standard) is the analytical standard of (+)-Cloprostenol. This product is intended for research and analytical applications. (+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.
    (+)-Cloprostenol (Standard)
  • HY-107382R
    RF9 (Standard) 876310-60-0 98%
    RF9 (Standard) is the analytical standard of RF9 (HY-107382). This product is intended for research and analytical applications. RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
    RF9 (Standard)
  • HY-107404R
    SID 7969543 (Standard) 868224-64-0 98%
    SID 7969543 (Standard) is the analytical standard of SID 7969543 (HY-107404). This product is intended for research and analytical applications. SID 7969543 is a selective SF-1 (steroidogenic factor 1, NR5A1) inhibitor with an IC50 of 760 nM. SID 7969543 inhibits SF-1-triggered luciferase expression with IC50 of 30 nM. SF-1 is a transcription factor belonging to the nuclear receptor superfamily.
    SID 7969543 (Standard)
  • HY-107456R
    E6130 (Standard) 1427058-33-0 98%
    E6130 (Standard) is the analytical standard of E6130 (HY-107456). This product is intended for research and analytical applications. E6130 is an orally active and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease.
    E6130 (Standard)
  • HY-107512R
    Kynurenic acid sodium (Standard) 2439-02-3 98%
    Kynurenic acid (sodium) (Standard) is the analytical standard of Kynurenic acid (sodium). This product is intended for research and analytical applications. Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8.
    Kynurenic acid sodium (Standard)
  • HY-107536R
    ML 145 (Standard) 1164500-72-4
    ML 145 (Standard) is the analytical standard of ML 145 (HY-107536). This product is intended for research and analytical applications. ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM). ML 145 has no significant activity for GPR35 at either rodent ortholog.
    ML 145 (Standard)
  • HY-107734R
    L 152804 (Standard) 6508-43-6 98%
    L 152804 (Standard) is the analytical standard of L 152804 (HY-107734). This product is intended for research and analytical applications. L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.
    L 152804 (Standard)
  • HY-107917R
    Desoxycorticosterone pivalate (Standard) 808-48-0
    Desoxycorticosterone pivalate (Standard) is the analytical standard of Desoxycorticosterone pivalate. This product is intended for research and analytical applications. Desoxycorticosterone pivalate (DOCP) is a mineralocorticoid hormone and an analog of Desoxycorticosterone. Desoxycorticosterone pivalate is used for the management of canine hypoadrenocorticism.
    Desoxycorticosterone pivalate (Standard)
  • HY-107987R
    CXCR7 modulator 1 (Standard) 2231812-31-8 98%
    CXCR7 modulator 1 (Standard) is the analytical standard of CXCR7 modulator 1 (HY-107987). This product is intended for research and analytical applications. CXCR7 modulator 1 (compound 25) is a potent and orally bioavailable peptoid hybrid CXCR7 modulator, with a Ki of 9 nM.
    CXCR7 modulator 1 (Standard)
  • HY-108045R
    Lodenafil carbonate (Standard) 398507-55-6
    Lodenafil carbonate (Standard) is the analytical standard of Lodenafil carbonate. This product is intended for research and analytical applications. Lodenafil carbonate, a dimer that acts as a proagent delivering Lodenafil in vivo, is an orally active phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED).
    Lodenafil carbonate (Standard)
  • HY-10805AR
    Almorexant hydrochloride (Standard) 913358-93-7 98%
    Almorexant hydrochloride (Standard) is the analytical standard of Almorexant (hydrochloride) (HY-10805A). This product is intended for research and analytical applications. Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular Ca2+ signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.
    Almorexant hydrochloride (Standard)
  • HY-108196R
    PTP1B-IN-15 (Standard) 765317-71-3 98%
    PTP1B-IN-15 (Standard) is the analytical standard of PTP1B-IN-15 (HY-108196). This product is intended for research and analytical applications. PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 has the potential for the research of type II diabetes and obesity.
    PTP1B-IN-15 (Standard)
Cat. No. Product Name / Synonyms Application Reactivity