2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-76737
    4-Chlorodiphenyl ether 7005-72-3 98%
    4-Chlorodiphenyl ether (4-CDE) is an estrogen-mimicking active compound. 4-Chlorodiphenyl ether maintains the survival of endometriotic cysts and exhibits estrogenic activity associated with the growth of endometriotic implants. 4-Chlorodiphenyl ether can be used in research related to endometriosis.
    4-Chlorodiphenyl ether
  • HY-77833
    RU 56279 143782-20-1 99.68%
    RU 56279 is an androgen receptor (AR) antagonist with strong and systemic anti-androgenic activity. RU 56279 is also a common, potent and long-lasting anti-androgen metabolite of RU 56187 (HY-117486) and RU 58841 (HY-10561) in vivo. RU 56279 can be used as an AR ligand to construct an AR-targeted prodrug system for the study of AR-positive tumor cells.
    RU 56279
  • HY-A0142
    Dapiprazole 72822-12-9 98%
    Dapiprazole is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole suppresses the opioid withdrawal symptoms. Dapiprazole is also used as eye drops for reversing mydriasis.
    Dapiprazole
  • HY-A0267
    Bitolterol 30392-40-6 98%
    Bitolterol is a β2-adrenergic agonist with bronchodilator activity. Bitolterol is classified as a prodrug and is primarily used for the suppression of respiratory diseases. Bitolterol is considered safe for use during breastfeeding, as the amount that can enter breast milk is very limited.
    Bitolterol
  • HY-B0431
    Phenoxybenzamine 59-96-1 98%
    Phenoxybenzamine is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine also shows antitumor activity.
    Phenoxybenzamine
  • HY-B0709
    Estradiol acetate 4245-41-4 98%
    Estradiol acetate is a novel orally active Estradiol (HY-B0141) prodrug. Estradiol acetate reduces the frequency and severity of postmenopause symptoms. Estradiol acetate can be used in the research of menopausal symptoms.
    Estradiol acetate
  • HY-B1001
    Todralazine 14679-73-3 98%
    Todralazine (Ecarazine) is an anti-hypertensive agent, acts as a β2AR blocker, with antioxidant and free radical scavenging activity.
    Todralazine
  • HY-B1034
    Vanitiolide 17692-71-6 98%
    Vanitiolide is a cholagogue.
    Vanitiolide
  • HY-B1617
    Zuclomiphene 15690-55-8 98%
    Zuclomiphene is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene can be for the researches of endocrinology and metabolic disease.
    Zuclomiphene
  • HY-B1711
    Norfenefrine 536-21-0
    Norfenefrine is an orally active, endogenously found α-adrenergic agonist and can be used for the research of female stress incontinence.
    Norfenefrine
  • HY-B1951
    Trietazine 1912-26-1 99.51%
    Trietazine is a selective pre- and post-emergence glyphosate-based herbicide. Trietazine residues cause human health risks, such as cancer, birth defects, and hormone imbalance.
    Trietazine
  • HY-D2379
    HMRG 1629965-68-9 98%
    HMRG is a type of hydroxymethyl rhodamine green fluorescent scaffold, featuring an open non-cyclic structure. HMRG can produce significant dynamic fluorescence changes through a one-step enzymatic reaction at physiological pH, which is useful for developing various probes. Fluorescent probes based on HMRG can be used for fluorescence detection of diseases such as tumors and diabetic nephropathy.
    HMRG
  • HY-D3235
    FDOCl-22 2540586-21-6 98%
    FDOCl-22 is a HOCl-responsive probe. FDOCl-22 reacts with hypochlorous acid to significantly enhance near-infrared emission and absorption signals, enabling the detection of HOCl levels associated with reagent-induced acute kidney injury. FDOCl-22 can be used in studies related to reagent-induced acute kidney injury.
    FDOCl-22
  • HY-N3257
    Millewanin G 874303-33-0 98%
    Millewanin G is a prenylated isoflavonoid with antiestrogenic activity (IC50=29 μM). Millewanin G can be isolated from the leaves of M. pachycarpa cultivated in Japan.
    Millewanin G
  • HY-N3503
    Ganoderlactone D 1801934-15-5 99.0%
    Ganoderlactone D shows inhibitory effects of yeast α-Glucosidase with IC50 values of 41.7 μM.
    Ganoderlactone D
  • HY-N5103
    Genistein 7,4'-di-O-β-D-glucoside 36190-98-4 99.96%
    Genistein 7,4'-di-O-β-D-glucoside is a natural product with significantly estrogenic proliferative effect in MCF-7 cells.
    Genistein 7,4'-di-O-β-D-glucoside
  • HY-N6181
    Terrelumamide A 1802497-05-7 98%
    Terrelumamide A is a lumazine-containing peptide. Terrelumamide A is isolated from the culture broth of the marine-derived fungus Aspergillus terreus. Terrelumamide A exhibits pharmacological activity by improving insulin sensitivity. Terrelumamide A has the potential in the application of DNA sequence recognition.
    Terrelumamide A
  • HY-N7241
    Saudin 94978-16-2 98%
    Saudin, derived from Clutia lanceolata, is a hypoglycemic compound that significantly enhances glucose-triggered insulin release from murine pancreatic islets. It belongs to a group of new diterpenoids with a distinct tetracyclic core, suggesting potential as a therapeutic agent for diabetes treatment. Proposed biosynthetic pathways outline alternative cyclization routes from a common precursor, with Lanceolide P (16) identified as a promising lead compound for further development in managing diabetes.
    Saudin
  • HY-N8170
    4',2-Dihydroxy-4,6-dimethoxydihydrochalcone 151752-07-7 98.0%
    4',2-Dihydroxy-4,6-dimethoxydihydrochalcone, an estrogen agonist, shows binding affinity for bovine uterine estrogen receptor with an IC5050 of 15 μM.
    4',2-Dihydroxy-4,6-dimethoxydihydrochalcone
  • HY-P0037
    Org-30850 136208-71-4 98%
    Org-30850 is a potent LHRH antagonist designed for treating hormone-dependent disorders. In animal studies, a single subcutaneous dose effectively inhibited ovulation in rats and significantly reduced testosterone levels in male rats for up to 48 hours post-administration. Daily doses of Org-30850 in female rats suppressed estrous cycles, decreased uterine and ovarian weights, and lowered estradiol and FSH serum levels. In male rats, prolonged treatment resulted in reversible reductions in gonadal function and testosterone levels, with almost complete recovery observed after cessation of treatment. Unlike comparable LHRH antagonists, Org-30850 exhibited minimal injection site irritation and no edematous reactions, suggesting a more favorable therapeutic profile.
    Org-30850
Cat. No. Product Name / Synonyms Application Reactivity