4-Chlorodiphenyl ether
Based on 1 Customer Validation
4-Chlorodiphenyl ether (4-CDE) is an estrogen-mimicking active compound. 4-Chlorodiphenyl ether maintains the survival of endometriotic cysts and exhibits estrogenic activity associated with the growth of endometriotic implants. 4-Chlorodiphenyl ether can be used in research related to endometriosis.
For research use only. We do not sell to patients.
- CAS No.: 7005-72-3
- Formula: C12H9ClO
- Molecular Weight:204.65
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
4-Chlorodiphenyl ether (68 nmol/kg; intravenous injection; single administration) is rapidly cleared from the blood of rays, mainly accumulates in the liver with slow elimination, and has a total body clearance rate of 4.05 mL·min−1·kg−1[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B6C3F1 (female, adult, 22-27 g, surgically induced endometriosis)[1]
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Dosage:10 mg/kg/day; 75 mg/kg/day; 150 mg/kg/day
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Administration:s.c.; daily; 28 days
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Result:Achieved 28% endometriotic cyst survival rate; showed no significant difference in cyst diameter compared to vehicle control; caused no significant alteration to hepatic BROD, MROD, EROD, or PROD enzyme activities relative to vehicle control.
Achieved 36% endometriotic cyst survival rate; showed no significant difference in cyst diameter compared to vehicle control; caused no significant alteration to hepatic BROD, MROD, EROD, or PROD enzyme activities relative to vehicle control.
Achieved 60% endometriotic cyst survival rate (significantly higher than vehicle control's 8%); showed no significant difference in cyst diameter compared to vehicle control; Significantly elevated hepatic BROD enzyme activity and significantly suppressed hepatic MROD enzyme activity relative to vehicle control, estrone-treated group, and 10/75 mg/kg/day 4-CDE groups; Resulted in hepatic EROD enzyme activity significantly lower than in the estrone-treated group; caused no significant alteration to hepatic PROD enzyme activity relative to vehicle control.
Chemical Information
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CAS No. 7005-72-3
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Appearance Liquid
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Molecular Weight 204.65
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Formula C12H9ClO
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SMILES
ClC1=CC=C(OC=2C=CC=CC2)C=C1
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Synonyms
4-CDE
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Chlorodiphenyl ether Related Classifications
HY-76737 Related Classifications
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- 4-Chlorodiphenyl ether
- 7005-72-3
- 4-CDE
- Estrogen Receptor/ERR
- hepatic microsomal methoxyresorufin-O-dealkylase
- hepatic microsomal benzyloxyresorufin-O-dealkylase
- B6C3F1 mice
- hepatic microsomal enzyme activity
- PROD activity
- endometriosis
- endometriotic implant growth
- cytochrome P450 isoforms
- endometriotic cysts
- winter skate
- Inhibitor
- inhibitor
- inhibit