2. Dapiprazole

Dapiprazole is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole suppresses the opioid withdrawal symptoms. Dapiprazole is also used as eye drops for reversing mydriasis.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Dapiprazole hydrochloride) usually boasts enhanced water solubility and stability.

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Dapiprazole Chemical Structure

Dapiprazole Chemical Structure

CAS No. : 72822-12-9

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Dapiprazole Related Antibodies

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Description

Dapiprazole is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole suppresses the opioid withdrawal symptoms. Dapiprazole is also used as eye drops for reversing mydriasis[1][2][3].

IC50 & Target

alpha-1 adrenoceptor[1]
In Vivo

Dapiprazole hydrochloride (0-10 mg/kg or 0-3 mg/mice; i.p. or i.c.v.; once) reduces the overall severity of the opiate withdrawal symptoms in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss Albino male CD-1 mice weighing 20 -25 g, acute dependence model[1]
Dosage: 5, 7.5 and 10 mg/kg (i.p.) or 0.5, 1 and 3 mg/mice (i.c.v.), once
Administration: Intraperitoneal injection or intracerebroventricular administration, once
Result: Decreased jumping behavior, head shakes and paw shakes when administered just before naloxone.
Molecular Weight

325.45

Formula

C19H27N5
CAS No.
SMILES

CC1=CC=CC=C1N2CCN(CCC3=NN=C4CCCCN43)CC2
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Room temperature in continental US; may vary elsewhere.
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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