Dapiprazole hydrochloride
Based on 1 Customer Validation
Dapiprazole hydrochloride is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole hydrochloride suppresses the opioid withdrawal symptoms. Dapiprazole hydrochloride is also used as eye drops for reversing mydriasis.
For research use only. We do not sell to patients.
- Purity: 99.26%
- CAS No.: 72822-13-0
- Formula: C19H28ClN5
- Molecular Weight:361.91
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Adrenergic Receptor Isoforms
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Biological Activity
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α1-adrenergic receptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss Albino male CD-1 mice weighing 20 -25 g, acute dependence model[1]
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Dosage:5, 7.5 and 10 mg/kg (i.p.) or 0.5, 1 and 3 mg/mice (i.c.v.), once
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Administration:Intraperitoneal injection or intracerebroventricular administration, once
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Result:Decreased jumping behavior, head shakes and paw shakes when administered just before naloxone.
Chemical Information
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CAS No. 72822-13-0
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Appearance Solid
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Molecular Weight 361.91
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Formula C19H28ClN5
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Color White to off-white
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SMILES
CC1=CC=CC=C1N2CCN(CCC3=NN=C4CCCCN43)CC2.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (276.31 mM; Need ultrasonic)
DMSO : 12.5 mg/mL (34.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (138.16 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Valeri P, et al. Effects of dapiprazole, clonidine and yohimbine on the development of dependence and withdrawal behaviour in mice. Drug Alcohol Depend. 1989 Jan;23(1):73-7. [Content Brief]
[2]. Allinson RW, et al. Reversal of mydriasis by dapiprazole. Ann Ophthalmol. 1990 Apr;22(4):131-3, 138. [Content Brief]
[3]. Hou RH, et al. Arousal and the pupil: why diazepam-induced sedation is not accompanied by miosis. Psychopharmacology (Berl). 2007 Nov;195(1):41-59. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.7631 mL | 13.8156 mL | 27.6312 mL | 69.0779 mL |
| 5 mM | 0.5526 mL | 2.7631 mL | 5.5262 mL | 13.8156 mL | |
| 10 mM | 0.2763 mL | 1.3816 mL | 2.7631 mL | 6.9078 mL | |
| 15 mM | 0.1842 mL | 0.9210 mL | 1.8421 mL | 4.6052 mL | |
| 20 mM | 0.1382 mL | 0.6908 mL | 1.3816 mL | 3.4539 mL | |
| 25 mM | 0.1105 mL | 0.5526 mL | 1.1052 mL | 2.7631 mL | |
| 30 mM | 0.0921 mL | 0.4605 mL | 0.9210 mL | 2.3026 mL | |
| H2O | 40 mM | 0.0691 mL | 0.3454 mL | 0.6908 mL | 1.7269 mL |
| 50 mM | 0.0553 mL | 0.2763 mL | 0.5526 mL | 1.3816 mL | |
| 60 mM | 0.0461 mL | 0.2303 mL | 0.4605 mL | 1.1513 mL | |
| 80 mM | 0.0345 mL | 0.1727 mL | 0.3454 mL | 0.8635 mL | |
| 100 mM | 0.0276 mL | 0.1382 mL | 0.2763 mL | 0.6908 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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