2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-163321
    DapE-IN-1 98%
    DapE-IN-1 (compound 3y) is a diaminopimelate desuccinylase (DapE) inhibitor and a potentially potent antibiotic.
    DapE-IN-1
  • HY-163337
    Antifungal agent 92 3020687-94-6 98%
    Antifungal agent 92 (Compound 21) is a potent antifungal agent with an EC50 of 4.4 μM against Sclerotinia sclerotiorum. Antifungal agent 92 can induce abnormal mitochondrial morphology, loss of mitochondrial membrane potential, and reactive oxygen species (ROS) accumulation in Sclerotinia sclerotiorum. Antifungal agent 92 is a moderate promiscuous inhibitor of mitochondrial complexes II and III.
    Antifungal agent 92
  • HY-163338
    Metallo-β-lactamase-IN-13 1802366-23-9 98%
    Metallo-β-lactamase-IN-13 (Compound 13i) is a pan Metallo-β-Lactamase inhibitor. Metallo-β-lactamase-IN-13 provides broader coverage of metallo-β-lactamases expressing Gram-negative (GN) bacteria. Metallo-β-lactamase-IN-13 has antibacterial activity against P. aeruginosa.
    Metallo-β-lactamase-IN-13
  • HY-163339
    Metallo-β-lactamase-IN-14 1802367-43-6 98%
    Metallo-β-lactamase-IN-14 (Compound 17e) is a Metallo-β-Lactamase inhibitor. Metallo-β-lactamase-IN-14 shows inhibition activity against VIM-1 and VIM-2. Metallo-β-lactamase-IN-14 has antibacterial activity against Gram-negative (GN) bacteria and P. aeruginosa.
    Metallo-β-lactamase-IN-14
  • HY-163342
    Antibacterial agent 190 98%
    Antibacterial agent 190 (compound 16) is a antibacterial agent. Antibacterial agent 190 shows antibacterial activity. Antibacterial agent 190 reduces the bacterial burden of the peritoneum and blood.
    Antibacterial agent 190
  • HY-163352
    Chitinase-IN-6 98%
    Chitinase-IN-6 (Compound 4h) is a potent dual-Chitinase inhibitor, with Ki values of 1.82 and 2.00 μM against OfChtI and OfChi-h, respectively. Chitinase-IN-6 exhibits certain growth inhibition effects against Ostrinia furnacalis. Chitinase-IN-6 is a potential novel insecticide candidate friendly to nontarget organisms.
    Chitinase-IN-6
  • HY-163353
    Antibacterial agent 193 3031243-11-2 98%
    Antibacterial agent 193 (Compound 2n) is A monobenzene derivative of spiromarone A, which has antibacterial activity against Rhizoctonia solani. with IC50 value of 5.25 μg/mL.
    Antibacterial agent 193
  • HY-163362
    HIV-1 inhibitor-65 98%
    HIV-1 inhibitor-65 (compound 3c) is an inhibitor of HIV-1 (EC50: 2.9 nM) and an activator of protein kinase C (PKC). HIV-1 inhibitor-65 inhibits syncytium formation (EC50: 7.0 nM) and inhibits HIV-1 entry and HIV-1 reverse transcriptase.
    HIV-1 inhibitor-65
  • HY-163364
    DS-22-inf-021 945170-74-1 98%
    DS-22-inf-021 is a neuraminidase (NA) inhibitor. DS-22-inf-021 has antiviral activity against influenza viruses.
    DS-22-inf-021
  • HY-163367
    MATE-IN-1 98%
    MATE-IN-1 (Compound 31) is an inhibitor of MATE,with EC50 value of 1.8 μM. MATE-IN-1 has antibacterial activity.
    MATE-IN-1
  • HY-163377
    AZ5385 848439-89-4 98%
    AZ5385 is an EGFR-tyrosine kinase inhibitor. AZ5385 is a HRV-2 virus blocker, with EC50 of 0.35 µM. AZ5385 affects the late stage of viral life cycle.
    AZ5385
  • HY-163383
    L-Ent-oxPt(IV) 98%
    L-Ent-oxPt IV (L-EOP) is a Oxaliplatin (HY-17371)-based siderophore-platinum conjugate. L-Ent-oxPt IV exhibits selectivity towards Escherichia coli and antibacterial activity through DNA damage.
    L-Ent-oxPt(IV)
  • HY-163389
    Mpro/Cathepsin L-IN-1 98%
    Mpro/Cathepsin L-IN-1 (Compound 4d) is a SARS-CoV-2 Mpro/hCatL inhibitor, with Kis of 5.54 μM and 0.701 μM respectively.
    Mpro/Cathepsin L-IN-1
  • HY-163392
    Neuraminidase-IN-17 2935407-34-2 98%
    Neuraminidase-IN-17 (compound N10) is a neuraminidase inhibitor with the EC50 of 0.11 μM. Neuraminidase-IN-17 shows antiviral activity in vitro.
    Neuraminidase-IN-17
  • HY-163393
    Neuraminidase-IN-18 2935407-32-0 98%
    Neuraminidase-IN-18 (compound N5) is a novel polyheterocyclic neuraminidase (NA) inhibitor. Neuraminidase-IN-18 shows potency in inhibition of H5N1 NA with an IC50 of 0.14 μM and 0.27 μM against the wild-type H5N1 NA and H5N1-H274Y mutant NA, respectively. Neuraminidase-IN-18 inhibits influenza virus replication by binding to NAs in cell level.
    Neuraminidase-IN-18
  • HY-163395
    3-Tosylimidazolidine-2,4-dione 98%
    3-Tosylimidazolidine-2,4-dione (compound 2C) is a hydantoins derivative, and exhibits inhibitory activity against the Pf3D7 strain, with an IC50 value of 3.97  nM.
    3-Tosylimidazolidine-2,4-dione
  • HY-163397
    Antibacterial agent 196 98%
    Antibacterial agent 196 (compound 6b) is a coumarin derivative containing oxime ether structure, and shows antifungal activity, with the EC50 of 0.46 μg/mL against Rhizoctonia solani .
    Antibacterial agent 196
  • HY-163399
    Antibacterial agent 197 54387-80-3 98%
    Antibacterial agent 197 (compound 1-deAA) is a termination inhibitor of non-classical anhydroglycosyl receptors and anhydrowall peptide-type peptidoglycan (PG) in bacterial TGase, with activity against Staphylococcus aureus. Antibacterial agent 197 synergizes with Vancomycin (HY-B0671) and is its antibacterial adjuvant.
    Antibacterial agent 197
  • HY-163404
    Urease-IN-13 3034860-91-5 98%
    Urease-IN-13 (compound d8) is an inhibitor of urease with an IC50 value of 1.21 μM. Urease-IN-13 can be used in the study of infectious gastritis and gastric ulcer.
    Urease-IN-13
  • HY-163437
    Antitubercular agent-45 3037164-59-0 98%
    Antitubercular agent-45 (Compound 5g) is an antifungal and antitubercular agent. Antitubercular agent-45 inhibits S. aureus, MRSA, B. subtilis, E. coli, C. albicans with MIC values of 6.4, 10.8, 6.1, 8.4 , 8.1 μM respectively.
    Antitubercular agent-45
Cat. No. Product Name / Synonyms Application Reactivity