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Cat. No.: HY-163395

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3-Tosylimidazolidine-2,4-dione

3-Tosylimidazolidine-2,4-dione (compound 2C) is a hydantoins derivative, and exhibits inhibitory activity against the Pf3D7 strain, with an IC₅₀ value of 3.97  nM.

For research use only. We do not sell to patients.

Formula: C₁₀H₁₀N₂O₄S
Molecular Weight:254.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

3-Tosylimidazolidine-2,4-dione Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

3-Tosylimidazolidine-2,4-dione (compound 2C) is a hydantoins derivative, and exhibits inhibitory activity against the Pf3D7 strain, with an IC₅₀ value of 3.97  nM^[1].

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MRC5	IC₅₀	>100 μM Compound: 2c	Cytotoxicity against human MRC5 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	[PMID: 38484804]

Chemical Information

Molecular Weight 254.26
Formula C₁₀H₁₀N₂O₄S
SMILES

CC1=CC=C(C=C1)S(=O)(N2C(CNC2=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chin EZ, et al. Synthesis and biological evaluation of hydantoin derivatives as potent antiplasmodial agents. Bioorg Med Chem Lett. Published online March 12, 2024. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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