2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-167900
    CMV-423 186829-19-6 98%
    CMV-423 is an antiviral agent with potent in vitro activity against the beta-herpesvirus human cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6) and 7 (HHV-7). CMV-423 can be utilized in antiviral research.
    CMV-423
  • HY-167911
    Cidofovir sodium 127749-27-3 98%
    Cidofovir sodium is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir sodium inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir sodium induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir sodium also has anti-orthopoxvirus and anti-variola activities.
    Cidofovir sodium
  • HY-167919
    1-(1-Adamantyl)-3-butyl-2-thiourea 25444-87-5 98%
    1-(1-Adamantyl)-3-butyl-2-thiourea is a compound with antiviral activity, demonstrating efficacy against various viral pathogens; 1-(1-Adamantyl)-3-butyl-2-thiourea serves as a potential therapeutic agent in the treatment of viral infections.
    1-(1-Adamantyl)-3-butyl-2-thiourea
  • HY-167945
    AMD-3329 170861-87-7 98%
    AMD-3329 is a potent and selective anti-HIV-1 and HIV-2 agent, exhibiting activity by inhibiting virus replication through binding to the chemokine receptor CXCR4, which serves as a co-receptor for the entry of X4 viruses.
    AMD-3329
  • HY-168004
    FolB-IN-1 98%
    FolB-IN-1 (Compound 3e) is an inhibitor of FolB that can suppress the activity of FolB enzyme from Mycobacterium tuberculosis (MtFolB). FolB-IN-1 exhibits antimycobacterial activity with an MIC value of 40 µg/mL (108 µM).
    FolB-IN-1
  • HY-168015
    5-Oxo leukotriene B4 195061-92-8 98%
    5-Oxo leukotriene B4 is a byproduct in the synthesis of 12-oxo LTB4 (HY-130497) with antiviral activity. 5-Oxo leukotriene B4 is promising for research of viral infections caused by human and animal enveloped RNA viruses.
    5-Oxo leukotriene B4
  • HY-168042
    Antibacterial agent 243 98%
    Antibacterial agent 243 is an antibacterial agent, with EC50 values of 0.64 mg/L for Valsa mali, 26 mg/L for allicin, and 0.33 mg/L for tebuconazole. Antibacterial agent 243 can induce hyphal shrinkage and collapse, trigger the accumulation of reactive oxygen species inside cells, regulate antioxidant enzyme activity, initiate lipid peroxidation, and ultimately cause irreversible oxidative damage to Valsa mali cells.
    Antibacterial agent 243
  • HY-168045
    HBV-IN-48 2743466-04-6 98%
    HBV-IN-48 is an HBV inhibitor. HBV-IN-48 has antiviral activity against HBV in HepDE19 cells, with an EC50 value of 0.005 μM. HBV-IN-48 can reduce serum HBV DNA levels in mouse models of HBV infection.
    HBV-IN-48
  • HY-168063
    Antibiofilm agent-11 98%
    Antibiofilm agent-11 (compound C12) is a xanthone derivative with anti-biofilm activity.
    Antibiofilm agent-11
  • HY-168066
    Antifungal agent 117 98%
    Antifungal agent 117 is a bis-pyrazole carboxamide derivative with antifungal activity, exhibiting an EC50 value of 11.58 mg/L against Sclerotinia sclerotiorum. Antifungal agent 117 increases cell membrane permeability, causing an imbalance in osmotic pressure inside and outside the cell, and induces the accumulation of reactive oxygen species (ROS), leading to oxidative damage to the cell membrane, resulting in leakage of cellular contents and eventually cell death. RNA sequencing analysis reveals that Antifungal agent 117 downregulates catalase genes and upregulates neutral ceramidase genes, disrupting cell membrane structure, accelerating sphingolipid metabolism, and promoting cell death. Antifungal agent 117 shows great potential in the fields of plant protection and antifungal infection.
    Antifungal agent 117
  • HY-168077
    Antibiofilm agent-12 480452-24-2 98%
    Antibiofilm agent-12 (Compound C13) is an antifungal agent that belongs to the class of carbazate derivatives. Antibiofilm agent-12 exhibits significant antifungal activity against Candida auris, with a MIC90 of 237.9 μM. By inhibiting the drug efflux pump activity of Candida auris and promoting ergosterol depletion, Antibiofilm agent-12 hinders biofilm formation and reduces the metabolic flexibility of Candida auris. Additionally, Antibiofilm agent-12 demonstrates antifungal activity in a Candida auris-infected C. elegans model.
    Antibiofilm agent-12
  • HY-168086
    LSD1-IN-35 2992690-04-5 98%
    LSD1-IN-35 (Compound Z-1) is a selective LSD1 Inhibitor (IC50: 108 nM). LSD1-IN-35 inhibits the demethylation on H3K4me1/2. LSD1-IN-35 is an immunomodulator. LSD1-IN-35 promotes response of gastric cancer cells to T-cell killing effect by decreasing PD-L1 expression and further attenuates the PD-1/PD-L1 interaction.
    LSD1-IN-35
  • HY-168100
    LpxC-IN-14 98%
    LpxC-IN-14 (compound 6i) is a potent LpxC inhibitor. LpxC-IN-14 shows antibacterial activity. LpxC-IN-14 shows low cytotoxicity. LpxC-IN-14 shows acceptable plasma protein binding.
    LpxC-IN-14
  • HY-168107
    SARS-CoV-2-IN-98 98%
    SARS-CoV-2-IN-98 (compound 38) is a SARS-CoV-2 inhibitor with the Kd of 0.73 μM and can be used for study of COVID-19.
    SARS-CoV-2-IN-98
  • HY-168108
    Antifungal agent 115 98%
    Antifungal agent 115 (compound 8n) is a non-competitive chitin synthase (CHS) inhibitor with an IC50 of 93 μM. Antifungal agent 115 demonstrates good selectivity and broad-spectrum antifungal activity, exhibiting significant efficacy against drug-resistant fungi. Antifungal agent 115 can be utilized in fungi infection research.
    Antifungal agent 115
  • HY-168109
    Antibacterial agent 246 98%
    Antibacterial agent 246 (compound A33) is a antibacterial agent and has minimum inhibitory concentrations (MICs) of 0.5-4 μg/mL against twenty-three Gram-positive bacteria. Antibacterial agent 246 in combination with Polymyxin E(HY-113678) E inhibits the growth of various Gram-negative bacteria with the fractional inhibitory concentration index of 0.066.
    Antibacterial agent 246
  • HY-168152
    SARS-CoV-2 3CLpro-IN-26 98%
    SARS-CoV-2 3CLpro-IN-26 (Compound (S,R)-4y) is an allosteric inhibitor for SARS-CoV-2 3CLpro with an IC50 of 0.43 μM. SARS-CoV-2 3CLpro-IN-26 exhibits good cell permeability and is able to effectively cross the cell membrane, after co-incubation with Vero-E6 cells.
    SARS-CoV-2 3CLpro-IN-26
  • HY-168184
    WJM280 98%
    WJM280 is an orally active antimalarial agent, with an EC50 of 0.04 μM for P. falciparum 3D7 parasites.
    WJM280
  • HY-168188
    CYP51-IN-21 3053864-59-5 98%
    CYP51-IN-21 (Compound A33) is a potent CYP51 inhibitor. CYP51-IN-21 shows excellent antifungal activities against pathogenic fungi and drug-resistant strains. CYP51-IN-21 inhibits the formation of fungal biofilm.
    CYP51-IN-21
  • HY-168204
    3-Acetyl-28-N-(3-guanidinobutoxy)-oleanolic acid 98%
    3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid (compound J1) is a potent antimicrobial agent. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid shows anti-gram-positive bacteria and fungi activity. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid can be used as antibiotic adjuvants. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic disrupts the bacterial cell membrane, inserts into the DNA, and binds to DNA gyrase. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic reduces microbial count in a mouse MRSA skin infection model and accelerates wound healing.
    3-Acetyl-28-N-(3-guanidinobutoxy)-oleanolic acid
Cat. No. Product Name / Synonyms Application Reactivity