2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W766785
    Tiamulin Fumarate-13C4 98%
    Tiamulin Fumarate-13C4 is the 13C-labeled Tiamulin. Tiamulin (Thiamutilin) fumarate is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin fumarate is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp.
    Tiamulin Fumarate-13C4
  • HY-W768245
    a-D-Galactose-1,2-13C2 1-phosphate potassium 98%
    a-D-Galactose-1,2-13C2 1-phosphate potassium is the 13C- and 15N-labeled a-D-Galactose (HY-121370). α-D-Galactose is a non-starch polysaccharide found in the bulb tissues of Lilium davidii var. unicolor Salisb. α-D-Galactose has anti-oxidation properties, anti-tumour activities, immunomodulatory effects and anti-HIV functions.
    a-D-Galactose-1,2-13C2 1-phosphate potassium
  • HY-W768856
    Artemether-13C,d3 98%
    Artemether-13C,d3 (Dihydroqinghaosu methyl ether-13C,d3) is the deuterium and 13C-labeled Artemether (HY-N0402). Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria.
    Artemether-13C,d3
  • HY-W769743
    Propineb-d3 (Technical grade) 98%
    Propineb-d3 (Technical grade) is the deuterium labeled Propineb (HY-119630). Propineb (Zinc propylenebis) is a compound widely used in fruit and vegetables cultures, due to its large spectrum of activity against fungal plant diseases.
    Propineb-d3 (Technical grade)
  • HY-W770090
    CF 1743-d7 98%
    CF 1743-d7 is the deuterium labeled Cf1743 (HY-107025). Cf1743 is a potent anti-varicella-zoster virus (VZV) bicyclic nucleoside analogue. Cf1743 has antiviral activity, with an IC50 of 3.3 μM for VZV thymidine kinase (TK).
    CF 1743-d7
  • HY-W770677
    9-Carboxymethoxymethylguanine-13C2,15N 98%
    9-Carboxymethoxymethylguanine-13C2,15N is the 13C- and 15N-labeled 9-Carboxymethoxymethylguanine (HY-137181). 9-Carboxymethoxymethylguanine is the main metabolite of Aciclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent.
    9-Carboxymethoxymethylguanine-13C2,15N
  • HY-W770956
    Cefotiam-13C,15N2 98%
    Cefotiam-13C,15N2 (SCE-963-13C,15N2) is the 13C- and 15N-labeled Cefotiam (HY-B0734). Cefotiam (SCE-963) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.
    Cefotiam-13C,15N2
  • HY-W773487
    FtsZ-IN-10 676995-91-8 98%
    FtsZ-IN-10 is a bacterial division inhibitor that interferes with the normal assembly of FtsZ. FtsZ-IN-10 specifically binds to Bacillus subtilis FtsZ monomers, thereby affecting their polymerization behavior. FtsZ-IN-10 may also activate nucleotide-free archaeal FtsZ to form ordered polymers. FtsZ-IN-10 can hinder the localization of FtsZ in the Z ring and inhibit bacterial cell division. Chlorinated analogs of FtsZ-IN-10 show the ability to inhibit the growth of antibiotic-resistant clinical isolates such as Staphylococcus aureus and Enterococci.
    FtsZ-IN-10
  • HY-W777351
    Etravirine-13C3 1189671-48-4 98%
    Etravirine-13C3 (R165335-13C3) is the 13C-labeled Etravirine (HY-90005). Etravirine (R165335; TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
    Etravirine-13C3
  • HY-W777442
    Cletoquine-d4 Oxalate 1216461-57-2 98%
    Cletoquine-d4 Oxalate is the deuterium labeled Cletoquine (oxalate) (HY-135810A). Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment.
    Cletoquine-d4 Oxalate
  • HY-W777613
    Jasmolin I 4466-14-2 98%
    Jasmolin I ((-)-Jasmolin I) is a pyrethrin ester found in Chrysanthemum cinerariifolium. Jasmolin I is a safe pesticide with rapid degradation.
    Jasmolin I
  • HY-W777618
    Cinerin II 121-20-0 98%
    Cinerin II ((+)-Cinerin II) is a pyrethrin ester found in Chrysanthemum cinerariifolium. Cinerin II is a safe pesticide with rapid degradation.
    Cinerin II
  • HY-W777922
    Nifursol-15N2,d2 1246833-64-6 98%
    Nifursol-15N2,d2 is the deuterium and 15N-labeled Nifursol (HY-B1703). Nifursol is an orally active veterinary antibiotic. Nifursol inhibits Histomonas meleagridis. Nifursol prevents histomoniasis in turkeys. Nifursol is widely used in studies of Escherichia coli gastroenteritis in Salmonella-infected poultry and aquatic animals.
    Nifursol-15N2,d2
  • HY-W778157
    S-Methyl thiomethanesulfonatel-13C 1309943-60-9 98%
    S-Methyl thiomethanesulfonate-13C (MMTS-13C) is the 13C-labeled S-Methyl thiomethanesulfonate (HY-W004461). S-Methyl thiomethanesulfonate (MMTS) is a sulfur-containing volatile organic compound produced by?plants?and bacteria and is an effective anti-oomycete agent.
    S-Methyl thiomethanesulfonatel-13C
  • HY-W778511
    Levulinic acid-13C3 1391051-93-6 98%
    Levulinic acid-13C3 (4-Oxovaleric acid-13C) is the 13C-labeled Levulinic acid (HY-Y0839). Levulinic acid is a precursor for the synthesis of biofuels, such as ethyl levulinate. Levulinic acid is also a 5-keto-pentanoic acid. Levulinic acid can be utilized by the cells as a cosubstrate for biopolymer synthesis. Levulinic acid can be used in antibacterial research.
    Levulinic acid-13C3
  • HY-W778990
    2-Deoxyuridine-1,2,3,4,5-13C5 478510-94-0 98%
    2-Deoxyuridine-1,2,3,4,5-13C5 is the 13C-labeled 2'-Deoxyuridine (HY-D0186). 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD).
    2-Deoxyuridine-1,2,3,4,5-13C5
  • HY-W779244
    1H-Pyrazole-3,4,5-d3 51038-79-0 99.89%
    1H-Pyrazole-3,4,5-d3 is the deuterium labeled 1H-pyrazole (HY-76228). 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities.
    1H-Pyrazole-3,4,5-d3
  • HY-W779377
    Erythromycin B 527-75-3
    Erythromycin B has anti-malarial activity and effectively inhibits the asexual reproduction of Plasmodium falciparum.
    Erythromycin B
  • HY-W779743
    NE58043 105462-25-7 98%
    NE58043 (Compound 21) is a nitrogen-containing bisphosphonate compound. NE58043 has no significant inhibitory activity against Entamoeba histolytica and Plasmodium falciparum with IC50 > 200 μM. NE58043 shows a LD50 of 171 μM for human nasopharyngeal carcinoma KB cells. NE58043 can be used for the research of cancer and infection, such as nasopharyngeal carcinoma.
    NE58043
  • HY-W780694
    PD 124816 112654-98-5 98%
    PD 124816 is an orally active fluoroquinolone antibiotic. PD 124816 exerts broad-spectrum antibacterial effects by inhibiting DNA gyrase (topoisomerase IV), and it has no cross-resistance with commonly used antibiotics. PD 124816 is effective against both Gram-positive and Gram-negative bacteria (MIC₉₀ ≤ 0.06 μg/mL), and the MIC₉₀ for anaerobic bacteria (Peptostreptococcus fragi) is 1 μg/mL. PD 124816 exhibits complete bactericidal activity in a mouse model of Mycobacterium leprae infection. PD 124816 can be used for studying mixed infections and infections caused by drug-resistant bacteria.
    PD 124816
Cat. No. Product Name / Synonyms Application Reactivity