1. Others Metabolic Enzyme/Protease Apoptosis
  2. Thymidylate Synthase Endogenous Metabolite Isotope-Labeled Compounds
  3. 2-Deoxyuridine-1,2,3,4,5-13C5

2-Deoxyuridine-1,2,3,4,5-13C5 is the 13C-labeled 2'-Deoxyuridine (HY-D0186). 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD).

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2-Deoxyuridine-1,2,3,4,5-<sup>13</sup>C<sub>5</sub>

2-Deoxyuridine-1,2,3,4,5-13C5 Estructura química

No. CAS : 478510-94-0

Tamaño Precio Stock Cantidad
500 μg En stock
1 mg En stock
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10 mg   Obtener un presupuesto  

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Other Forms of 2-Deoxyuridine-1,2,3,4,5-13C5:

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Descripciòn

2-Deoxyuridine-1,2,3,4,5-13C5 is the 13C-labeled 2'-Deoxyuridine (HY-D0186). 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD)[1][2][3].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

233.17

Fòrmula

C413C5H12N2O5

No. CAS
Unlabeled CAS
SMILES

O[13C@H]1[13CH2][13C@@H](O[13C@@H]1[13CH2]O)N(C(N2)=O)C=CC2=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación
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Inquiry Information

Nombre del producto:
2-Deoxyuridine-1,2,3,4,5-13C5
Cat. No.:
HY-W778990
Cantidad:
MCE Japan Authorized Agent: